https://www.dolcera.com/wiki/index.php?title=File:SAR_map.gif&feed=atom&action=historyFile:SAR map.gif - Revision history2024-03-29T08:52:39ZRevision history for this page on the wikiMediaWiki 1.24wmf12https://www.dolcera.com/wiki/index.php?title=File:SAR_map.gif&diff=1718&oldid=prevVinod.singh@dolcera.com: Finasteride is well know compound for treatment of alopecia. Which inhibit the Type II 5-α-reductase activity. The figure shows the basic SAR for 4-azasteroids at 5- -reductase (published in a review by Kenny et al). In general, a ketone in the 3-positi2006-05-10T07:08:54Z<p>Finasteride is well know compound for treatment of alopecia. Which inhibit the Type II 5-α-reductase activity. The figure shows the basic SAR for 4-azasteroids at 5- -reductase (published in a review by Kenny et al). In general, a ketone in the 3-positi</p>
<p><b>New page</b></p><div>Finasteride is well know compound for treatment of alopecia. Which inhibit the Type II 5-α-reductase activity. The figure shows the basic SAR for 4-azasteroids at 5- -reductase (published in a review by Kenny et al). In general, a ketone in the 3-position is preferred. Lipophilic substituents in the 17-position are thought to bind in a lipophilic pocket of the receptor. Small lipophilic groups are tolerated around the ring as well as expanding the A-ring from six to seven-membered. The size and shape of the amide substituents at C-17 may influence both selectivity between types I and II and potency at both isoforms. Other structural classes of molecules are known to bind to 5 -R including 10 and 6-azasteroids, benzoquinolinones, benzoylaminophenoxybutanoic acid derivatives, and polyunsaturated fatty acids</div>Vinod.singh@dolcera.com