Changes
==Overview==
*Choline is an organic compound, usually grouped within the Vitamin B complex. Choline is available in various forms namely, choline bitartrate, choline citrate,choline chloride and others.
* '''Choline Bitartrate''' (L(+) choline bitartrate) is a colorless or white crystal powder, which is a water-soluble part of the B Vitamin family. The body needs B vitamins to manufacture neurotransmitters, chemicals that control alertness and mood by speeding nerve signals through the brain.
* There are eight B vitamins in the Vitamin B complex family. Although each performs a different function in the body, they all work together to maintain good health.
* As B vitamins are water soluble, they are excreted in the urine and can be quickly depleted from the body. Only a small amount is stored in the body. Because of this, it is important that we take supplements to replenish these important vitamins in our body. [http://www.add-adhd-help-center.com/Ingredients/choline_bitartrate.htm Source]
* Choline bitartrate is an essential nutrient needed by the nervous system to produce acetylcholine. Acetylcholine is a neurotransmitter that facilitates the transmission of impulses between neurons.
'''Natural Source of Choline bitartrate''': Egg yolk, peanuts, wheat germ, organ meats and legumes.
'''Health Benefits of Choline Bitartrate''':
* Being a product of vitamin, it can be applied to medicine, healthcare product and food.
* It is a nutritious additive and fat remover, enhance fatty metabolism and eliminate the accumulation of fat in liver.
* Influence muscle contractions, movement, coordination and enhance memory.
* Involved in higher level brain functions like memory, thought and intellect.
* Is vital to the structural integrity of cell walls, the production of amino acids and proteins and the metabolism of fats.
* Aid in the treatment of Alzheimer’s Disease, manic depression and improve the symptoms of Parkinson’s Disease.
'''Deficiencies in B vitamins causes''':
* Depression or signs of decreased mental functioning.
* Decrease cognitive function.
==Intellectual Property==
===Search Strategy===
* Databases: USG USA EPA EPB WO JP DEG DEA DET DEU GBA FRA
* Years: From 1836 - To April 18, 2009.
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#99CCFF"|'''S.No'''
|align = "center" bgcolor = "#99CCFF"|'''Concept'''
|align = "center" bgcolor = "#99CCFF"|'''Scope'''
|align = "center" bgcolor = "#99CCFF"|'''Search Query'''
|align = "center" bgcolor = "#99CCFF"|'''Hits'''
|-
|align = "center" bgcolor = "#99CCFF"|'''1'''
|bgcolor = "#99CCFF"|'''Choline bitartarate'''
|Full Spec.
|align = "center"|((choline ADJ1 bitartarate<nowiki>*</nowiki>) OR (choline ADJ1 bitartrate<nowiki>*</nowiki>) OR (choline ADJ1 bi ADJ1 tartrate<nowiki>*</nowiki>) OR (2-Hydroxyethyl ADJ1 trimethyl ADJ1 ammonium ADJ1 bitartrate) OR ((2-Hydroxyethyl) ADJ1 trimethyl ADJ1 ammonium ADJ1 bitartrate) OR ((2-Hydroxyethyl)trimethylammonium ADJ1 bitartrate))
|align = "center"|'''1016 hits'''
|-
|align = "center" bgcolor = "#99CCFF"|'''2'''
|bgcolor = "#99CCFF"|'''Food & beverage'''
|Claims, Title or Abstract
|align = "center"|(beverage<nowiki>*</nowiki> OR drink<nowiki>*</nowiki> OR juice<nowiki>*</nowiki> OR potion OR tonic OR spirit<nowiki>*</nowiki> OR (liquid ADJ1 refreshment) OR Tea OR milk OR coffee OR cocoa OR (liquid ADJ (formulation<nowiki>*</nowiki>1 OR preparation<nowiki>*</nowiki>1)) OR capsule<nowiki>*</nowiki> OR caplet<nowiki>*</nowiki> OR tablet<nowiki>*</nowiki> OR powder<nowiki>*</nowiki>2 OR (Nutri<nowiki>*</nowiki> ADJ supplement<nowiki>*</nowiki>) OR Food<nowiki>*</nowiki> OR Meal<nowiki>*</nowiki> OR composition OR (Nutrition<nowiki>*</nowiki> NEAR3 adjuvant<nowiki>*</nowiki> ) OR (food NEAR3 supplement<nowiki>*</nowiki>) OR formula OR formulation<nowiki>*</nowiki>)
|align = "center"|''' 3677912 hits'''
|-
|align = "center" bgcolor = "#99CCFF"|'''3'''
|bgcolor = "#99CCFF"|
|Combine
|align = "center"|'''1AND 2'''
|align = "center"|''' 881 hits (Unique Records 440)'''
|-
|}
===Analysis Taxonomy===
[[image:Choline bitartarate updated.jpeg|center|750 px|thumb|]]
====IP activity over the years====
* Maximum number of patents have been filed in the year 2004.
* Patents are published 18 months after application.
[[Image: CBT IP Trend.jpg|center|700 px|thumb|Graph showing IP Activity Over Years (Assignee versus earliest priority year)]]
====Top Assignees====
*Council of Scientific & Industrial Research found to be the Top assignee with 3 patents.
* For 2 patent / publications Asssignee name is not available.
[[Image:CBT TOP assignee.jpg|center|600 px|thumb|Graph showing Top assignee names]]
====Patent Focus====
* Patents focusing on Composition.
* Patents focusing on Methods.
* Patents focusing on Composition and Methods.
* Patents focusing on process of prepration.
[[Image:CBT pie chart.jpg|center|600 px|thumb|Graph showing patents focusing on composition / methods or Both]]
====Action of Choline bitartrate containing Compositions====
<mm>[[Cbt_cadbury.mm]]</mm>
====Choline Bitartarate Patents categorised as per formulation====
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#FF9900"|'''Product form'''
|align = "center" bgcolor = "#FF9900"|'''Patent/publication'''
|align = "center" bgcolor = "#FF9900"|'''Patent focus'''
|align = "center" bgcolor = "#FF9900"|'''Ingredients other than Choline Bitartarate'''
|align = "center" bgcolor = "#FF9900"|'''Application'''
|-
|align = "center" rowspan = "16"|'''Beverage / liquid / Drink'''
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040005368%22.PGNR.&OS=DN/20040005368&RS=DN/20040005368 US20040005368A1]
|align = "center"|Composition and Method
|1. At least one substance that enhance oxygen uptake such as Gingko A, Caffeine, Green Tea, L-pyroglutamate, Xanthinol nicotinate.<br>2. A protein supplement.
|Used for weight loss.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040191294%22.PGNR.&OS=DN/20040191294&RS=DN/20040191294 US20040191294A1]
|align = "center"|Composition, Method, Process of prepration
|1. one or more omega 3 fatty acids.<br>2. milk or milk-based products .
|lowers levels of cholesterol and triglycerides.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060121158%22.PGNR.&OS=DN/20060121158&RS=DN/20060121158 US20060121158A1]
|align = "center"|Composition
|1. A first ingredient comprising at least one of a polyol, a fiber or a combination thereof.<br>2. Second ingredient comprising calcium. <br>3. Third ingredient comprising at least one of flavanol, stimulant and antioxidant.
| Used for weight management.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5626849.PN.&OS=PN/5626849&RS=PN/5626849 US5626849A]
|align = "center"|Composition and Method
|An essentially dry mixture of chromium, L-carnitine, gamma-linolenic acid, (-) hydroxycitric acid, inositol, antioxidants and herbs.
|A dietary supplement to help facilitate weight loss
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5904948.PN.&OS=PN/5904948&RS=PN/5904948 US5904948A]
|align = "center"|Composition and Process of prepration
|An protein component and a carbohydrate component.
|Nutritional Supplement
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2006052231&F=0 WO2006052231A1]
|align = "center"|Composition and Process of prepration
|Sugar including the carbohydrates, fructose and maltodextrin, and electrolytes chromium, copper, potassium, magnesium, sodium, and citric acid.
|Restoring human growth hormone.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050171034%22.PGNR.&OS=DN/20050171034&RS=DN/20050171034 US20050171034A1]
|align = "center"|Composition and Method
|Betaine, pyridoxal-5-phosphate, and N-acetyl-cysteine.
|Promotes decrease of homocysteine levels in humans.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060241077%22.PGNR.&OS=DN/20060241077&RS=DN/20060241077 US20060241077A1]
|align = "center"|Composition and Method
|A uridine, an acyl derivative thereof, a uridine phosphate, uracil, or a salt thereof;
|Ameliorating or inhibiting decline in memory or intelligence.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070065456%22.PGNR.&OS=DN/20070065456&RS=DN/20070065456 US20070065456A1]
|align = "center"|Composition
|Wasabia japonica, Silybum marianum, Cynara scolymus.
|Nutritional supplement for a human diet.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070248696%22.PGNR.&OS=DN/20070248696&RS=DN/20070248696 US20070248696A1]
|align = "center"|Composition and Method
|Dimethylaminoethanol, cytidine 5<nowiki>’</nowiki>-diphosphocholine, turmeric extract, decaffeinated green tea extract, vitamin B1,B5, B6, B12,folic acid, Dimethylglycine, huperzine A, Griffonia simplicifolia extract and 1-phenylalanine.
|Improves neuromuscular facilitation and enhances cognitive functions, such as memory and mental focus.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220080317868%22.PGNR.&OS=DN/20080317868&RS=DN/20080317868 US20080317868A1]
|align = "center"|Composition
|An energy content, a protein fraction, a lipids fraction, a nucleotide fraction and a mineral fraction.
|An anti-allergic infant formulation.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4497800.PN.&OS=PN/4497800&RS=PN/4497800 US4497800A]
|align = "center"|Composition
|A protein equivalent, a suitable lipid, a carbohydrate component , essential vitamins , minerals and an emulsion stabilizer.
|Providing nourishment for a human patient in need of such nourishment .
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4499076.PN.&OS=PN/4499076&RS=PN/4499076 US4499076A]
|align = "center"|Composition
|Essential amino acids, carbohydrates, fats, vitamins namely vitamin A, B1, B6, B12, C, D2, E, K1, calcium pantothenate, nicotinic acid amide, biotin, folic acid or choline bitartrate and minerals.
|New elemental diets for liver diseases.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4837219.PN.&OS=PN/4837219&RS=PN/4837219 US4837219A]
|align = "center"|Composition, Method, Process of prepration
|L-Tyrosine, L-Phenylalanime, L-Leucine, Zinc (from Zinc Gluconate) and Copper (from Copper Gluconate).
|A medication for Alzheimer<nowiki>’</nowiki>s disease.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5437880.PN.&OS=PN/5437880&RS=PN/5437880 US5437880A]
|align = "center"|Composition
|Digestible saccharide and a carotenoid.
|A health drink
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO9415488&F=0 WO1994015488A2]
|align = "center"|Composition
|Carbohydrate, electrolyte, ammonia neutralizer, energy enhancer namely choline Bitartrate and others , antioxidant, neuromuscular function enhancer.
|
|-
|align = "center" rowspan = "2"|'''Foodstuff'''
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050208191%22.PGNR.&OS=DN/20050208191&RS=DN/20050208191 US20050208191A1]
|align = "center"|Composition and Process of prepration
|Whole wheat, Roasted (defatted) soy Peanut paste, Sesame seed paste Sesame seed , Wheat germ (roasted), Non fat dry milk, Sugar Powder, Liquid, Lecithin, Sodium Chloride, mmonium bicarbonate, vitamins and others.
|Nutritious baked snack food with high protein content
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2005087018&F=0 WO2005087018A1]
|align = "center"|Composition and Process of prepration
|vegetable sources as wheat flout, roasted peanut paste, sesame seed, soybean flour and well balanced mixture of vitamins, minerals and others.
|Food stuff for children and adult supplementing their nutritional requirement.
|-
|}
====White space analysis====
*[[Click here for table showing all the ingrediebts used along with Choline Bitartarate.]]
*'''[[Media:cbt containing compositions.xls|Click here]]''' for excel sheet showing Choline Bitartarate containing composition mentioned in Patents.
===Patent Analysis Sheets===
*'''[[Media:cbt Patent Analysis sheet.xls|Click here for the complete Analysis spread sheet-22 ON Targets]]'''
* '''[[Media:Other than cbt ingredients.xls|Click here]]''' for list of ingredients that are in combination with Choline Bitartarate, obtained from Patents.
===Scientific Literature Analysis===
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#FFCC99"|'''S.No.'''
|align = "center" bgcolor = "#FFCC99"|'''Title'''
|align = "center" bgcolor = "#FFCC99"|'''Citations'''
|align = "center" bgcolor = "#CCFFCC"|'''Publication Date'''
|align = "center" bgcolor = "#CCFFCC"|'''Results / Statastical data'''
|align = "center" bgcolor = "#CCFFCC"|'''Dolcera Summary'''
|-
|align = "center" bgcolor = "#FFCC99"|'''1'''
|Effect of choline supplementation on fatigue in trained cyclists.
|<font color="#0000FF"><u>[http://www.ncbi.nlm.nih.gov/pubmed/7674870 Med Sci Sports Exerc. 1995 May;27(5):668-73.]</u></font>
|align = "center"|1995-05-01
|1. Twenty male cyclists (ages 23-29) with maximal aerobic power (VO2max) between 58 and 81 ml.min-1.kg-1 were randomly divided into BRIEF (N = 10) and PROLONGED (N = 10) groups. <br>2. One hour after drinking a beverage with or without choline bitartrate (2.43 g), cyclists began riding at a power output equivalent to approximately 150% (BRIEF) and 70% (PROLONGED) of VO2max at a cadence of 80-90 rpm. <br>3.Time to exhaustion, indirect calorimetry and serum choline, lactate, and glucose were measured.
|Trained cyclists do not deplete choline during supramaximal brief or prolonged submaximal exercise, nor do they benefit from choline supplementation to delay fatigue under given conditions.
|-
|}
*'''[[Media:cbt Non_Patent Analysis sheet.xls|Click here for Scientific Literature Analysis spread sheet]]'''
==Dashboard==
* Click at this link for '''[http://client.dolcera.com/dashboard/dashboard.html?workfile_id=554 Dashboard]'''
*Choline is an organic compound, usually grouped within the Vitamin B complex. Choline is available in various forms namely, choline bitartrate, choline citrate,choline chloride and others.
* '''Choline Bitartrate''' (L(+) choline bitartrate) is a colorless or white crystal powder, which is a water-soluble part of the B Vitamin family. The body needs B vitamins to manufacture neurotransmitters, chemicals that control alertness and mood by speeding nerve signals through the brain.
* There are eight B vitamins in the Vitamin B complex family. Although each performs a different function in the body, they all work together to maintain good health.
* As B vitamins are water soluble, they are excreted in the urine and can be quickly depleted from the body. Only a small amount is stored in the body. Because of this, it is important that we take supplements to replenish these important vitamins in our body. [http://www.add-adhd-help-center.com/Ingredients/choline_bitartrate.htm Source]
* Choline bitartrate is an essential nutrient needed by the nervous system to produce acetylcholine. Acetylcholine is a neurotransmitter that facilitates the transmission of impulses between neurons.
'''Natural Source of Choline bitartrate''': Egg yolk, peanuts, wheat germ, organ meats and legumes.
'''Health Benefits of Choline Bitartrate''':
* Being a product of vitamin, it can be applied to medicine, healthcare product and food.
* It is a nutritious additive and fat remover, enhance fatty metabolism and eliminate the accumulation of fat in liver.
* Influence muscle contractions, movement, coordination and enhance memory.
* Involved in higher level brain functions like memory, thought and intellect.
* Is vital to the structural integrity of cell walls, the production of amino acids and proteins and the metabolism of fats.
* Aid in the treatment of Alzheimer’s Disease, manic depression and improve the symptoms of Parkinson’s Disease.
'''Deficiencies in B vitamins causes''':
* Depression or signs of decreased mental functioning.
* Decrease cognitive function.
==Intellectual Property==
===Search Strategy===
* Databases: USG USA EPA EPB WO JP DEG DEA DET DEU GBA FRA
* Years: From 1836 - To April 18, 2009.
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#99CCFF"|'''S.No'''
|align = "center" bgcolor = "#99CCFF"|'''Concept'''
|align = "center" bgcolor = "#99CCFF"|'''Scope'''
|align = "center" bgcolor = "#99CCFF"|'''Search Query'''
|align = "center" bgcolor = "#99CCFF"|'''Hits'''
|-
|align = "center" bgcolor = "#99CCFF"|'''1'''
|bgcolor = "#99CCFF"|'''Choline bitartarate'''
|Full Spec.
|align = "center"|((choline ADJ1 bitartarate<nowiki>*</nowiki>) OR (choline ADJ1 bitartrate<nowiki>*</nowiki>) OR (choline ADJ1 bi ADJ1 tartrate<nowiki>*</nowiki>) OR (2-Hydroxyethyl ADJ1 trimethyl ADJ1 ammonium ADJ1 bitartrate) OR ((2-Hydroxyethyl) ADJ1 trimethyl ADJ1 ammonium ADJ1 bitartrate) OR ((2-Hydroxyethyl)trimethylammonium ADJ1 bitartrate))
|align = "center"|'''1016 hits'''
|-
|align = "center" bgcolor = "#99CCFF"|'''2'''
|bgcolor = "#99CCFF"|'''Food & beverage'''
|Claims, Title or Abstract
|align = "center"|(beverage<nowiki>*</nowiki> OR drink<nowiki>*</nowiki> OR juice<nowiki>*</nowiki> OR potion OR tonic OR spirit<nowiki>*</nowiki> OR (liquid ADJ1 refreshment) OR Tea OR milk OR coffee OR cocoa OR (liquid ADJ (formulation<nowiki>*</nowiki>1 OR preparation<nowiki>*</nowiki>1)) OR capsule<nowiki>*</nowiki> OR caplet<nowiki>*</nowiki> OR tablet<nowiki>*</nowiki> OR powder<nowiki>*</nowiki>2 OR (Nutri<nowiki>*</nowiki> ADJ supplement<nowiki>*</nowiki>) OR Food<nowiki>*</nowiki> OR Meal<nowiki>*</nowiki> OR composition OR (Nutrition<nowiki>*</nowiki> NEAR3 adjuvant<nowiki>*</nowiki> ) OR (food NEAR3 supplement<nowiki>*</nowiki>) OR formula OR formulation<nowiki>*</nowiki>)
|align = "center"|''' 3677912 hits'''
|-
|align = "center" bgcolor = "#99CCFF"|'''3'''
|bgcolor = "#99CCFF"|
|Combine
|align = "center"|'''1AND 2'''
|align = "center"|''' 881 hits (Unique Records 440)'''
|-
|}
===Analysis Taxonomy===
[[image:Choline bitartarate updated.jpeg|center|750 px|thumb|]]
====IP activity over the years====
* Maximum number of patents have been filed in the year 2004.
* Patents are published 18 months after application.
[[Image: CBT IP Trend.jpg|center|700 px|thumb|Graph showing IP Activity Over Years (Assignee versus earliest priority year)]]
====Top Assignees====
*Council of Scientific & Industrial Research found to be the Top assignee with 3 patents.
* For 2 patent / publications Asssignee name is not available.
[[Image:CBT TOP assignee.jpg|center|600 px|thumb|Graph showing Top assignee names]]
====Patent Focus====
* Patents focusing on Composition.
* Patents focusing on Methods.
* Patents focusing on Composition and Methods.
* Patents focusing on process of prepration.
[[Image:CBT pie chart.jpg|center|600 px|thumb|Graph showing patents focusing on composition / methods or Both]]
====Action of Choline bitartrate containing Compositions====
<mm>[[Cbt_cadbury.mm]]</mm>
====Choline Bitartarate Patents categorised as per formulation====
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#FF9900"|'''Product form'''
|align = "center" bgcolor = "#FF9900"|'''Patent/publication'''
|align = "center" bgcolor = "#FF9900"|'''Patent focus'''
|align = "center" bgcolor = "#FF9900"|'''Ingredients other than Choline Bitartarate'''
|align = "center" bgcolor = "#FF9900"|'''Application'''
|-
|align = "center" rowspan = "16"|'''Beverage / liquid / Drink'''
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040005368%22.PGNR.&OS=DN/20040005368&RS=DN/20040005368 US20040005368A1]
|align = "center"|Composition and Method
|1. At least one substance that enhance oxygen uptake such as Gingko A, Caffeine, Green Tea, L-pyroglutamate, Xanthinol nicotinate.<br>2. A protein supplement.
|Used for weight loss.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040191294%22.PGNR.&OS=DN/20040191294&RS=DN/20040191294 US20040191294A1]
|align = "center"|Composition, Method, Process of prepration
|1. one or more omega 3 fatty acids.<br>2. milk or milk-based products .
|lowers levels of cholesterol and triglycerides.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060121158%22.PGNR.&OS=DN/20060121158&RS=DN/20060121158 US20060121158A1]
|align = "center"|Composition
|1. A first ingredient comprising at least one of a polyol, a fiber or a combination thereof.<br>2. Second ingredient comprising calcium. <br>3. Third ingredient comprising at least one of flavanol, stimulant and antioxidant.
| Used for weight management.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5626849.PN.&OS=PN/5626849&RS=PN/5626849 US5626849A]
|align = "center"|Composition and Method
|An essentially dry mixture of chromium, L-carnitine, gamma-linolenic acid, (-) hydroxycitric acid, inositol, antioxidants and herbs.
|A dietary supplement to help facilitate weight loss
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5904948.PN.&OS=PN/5904948&RS=PN/5904948 US5904948A]
|align = "center"|Composition and Process of prepration
|An protein component and a carbohydrate component.
|Nutritional Supplement
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2006052231&F=0 WO2006052231A1]
|align = "center"|Composition and Process of prepration
|Sugar including the carbohydrates, fructose and maltodextrin, and electrolytes chromium, copper, potassium, magnesium, sodium, and citric acid.
|Restoring human growth hormone.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050171034%22.PGNR.&OS=DN/20050171034&RS=DN/20050171034 US20050171034A1]
|align = "center"|Composition and Method
|Betaine, pyridoxal-5-phosphate, and N-acetyl-cysteine.
|Promotes decrease of homocysteine levels in humans.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060241077%22.PGNR.&OS=DN/20060241077&RS=DN/20060241077 US20060241077A1]
|align = "center"|Composition and Method
|A uridine, an acyl derivative thereof, a uridine phosphate, uracil, or a salt thereof;
|Ameliorating or inhibiting decline in memory or intelligence.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070065456%22.PGNR.&OS=DN/20070065456&RS=DN/20070065456 US20070065456A1]
|align = "center"|Composition
|Wasabia japonica, Silybum marianum, Cynara scolymus.
|Nutritional supplement for a human diet.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070248696%22.PGNR.&OS=DN/20070248696&RS=DN/20070248696 US20070248696A1]
|align = "center"|Composition and Method
|Dimethylaminoethanol, cytidine 5<nowiki>’</nowiki>-diphosphocholine, turmeric extract, decaffeinated green tea extract, vitamin B1,B5, B6, B12,folic acid, Dimethylglycine, huperzine A, Griffonia simplicifolia extract and 1-phenylalanine.
|Improves neuromuscular facilitation and enhances cognitive functions, such as memory and mental focus.
|-
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220080317868%22.PGNR.&OS=DN/20080317868&RS=DN/20080317868 US20080317868A1]
|align = "center"|Composition
|An energy content, a protein fraction, a lipids fraction, a nucleotide fraction and a mineral fraction.
|An anti-allergic infant formulation.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4497800.PN.&OS=PN/4497800&RS=PN/4497800 US4497800A]
|align = "center"|Composition
|A protein equivalent, a suitable lipid, a carbohydrate component , essential vitamins , minerals and an emulsion stabilizer.
|Providing nourishment for a human patient in need of such nourishment .
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4499076.PN.&OS=PN/4499076&RS=PN/4499076 US4499076A]
|align = "center"|Composition
|Essential amino acids, carbohydrates, fats, vitamins namely vitamin A, B1, B6, B12, C, D2, E, K1, calcium pantothenate, nicotinic acid amide, biotin, folic acid or choline bitartrate and minerals.
|New elemental diets for liver diseases.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4837219.PN.&OS=PN/4837219&RS=PN/4837219 US4837219A]
|align = "center"|Composition, Method, Process of prepration
|L-Tyrosine, L-Phenylalanime, L-Leucine, Zinc (from Zinc Gluconate) and Copper (from Copper Gluconate).
|A medication for Alzheimer<nowiki>’</nowiki>s disease.
|-
|[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5437880.PN.&OS=PN/5437880&RS=PN/5437880 US5437880A]
|align = "center"|Composition
|Digestible saccharide and a carotenoid.
|A health drink
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO9415488&F=0 WO1994015488A2]
|align = "center"|Composition
|Carbohydrate, electrolyte, ammonia neutralizer, energy enhancer namely choline Bitartrate and others , antioxidant, neuromuscular function enhancer.
|
|-
|align = "center" rowspan = "2"|'''Foodstuff'''
|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050208191%22.PGNR.&OS=DN/20050208191&RS=DN/20050208191 US20050208191A1]
|align = "center"|Composition and Process of prepration
|Whole wheat, Roasted (defatted) soy Peanut paste, Sesame seed paste Sesame seed , Wheat germ (roasted), Non fat dry milk, Sugar Powder, Liquid, Lecithin, Sodium Chloride, mmonium bicarbonate, vitamins and others.
|Nutritious baked snack food with high protein content
|-
|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2005087018&F=0 WO2005087018A1]
|align = "center"|Composition and Process of prepration
|vegetable sources as wheat flout, roasted peanut paste, sesame seed, soybean flour and well balanced mixture of vitamins, minerals and others.
|Food stuff for children and adult supplementing their nutritional requirement.
|-
|}
====White space analysis====
*[[Click here for table showing all the ingrediebts used along with Choline Bitartarate.]]
*'''[[Media:cbt containing compositions.xls|Click here]]''' for excel sheet showing Choline Bitartarate containing composition mentioned in Patents.
===Patent Analysis Sheets===
*'''[[Media:cbt Patent Analysis sheet.xls|Click here for the complete Analysis spread sheet-22 ON Targets]]'''
* '''[[Media:Other than cbt ingredients.xls|Click here]]''' for list of ingredients that are in combination with Choline Bitartarate, obtained from Patents.
===Scientific Literature Analysis===
{|border="2" cellspacing="0" cellpadding="4" width="100%"
|align = "center" bgcolor = "#FFCC99"|'''S.No.'''
|align = "center" bgcolor = "#FFCC99"|'''Title'''
|align = "center" bgcolor = "#FFCC99"|'''Citations'''
|align = "center" bgcolor = "#CCFFCC"|'''Publication Date'''
|align = "center" bgcolor = "#CCFFCC"|'''Results / Statastical data'''
|align = "center" bgcolor = "#CCFFCC"|'''Dolcera Summary'''
|-
|align = "center" bgcolor = "#FFCC99"|'''1'''
|Effect of choline supplementation on fatigue in trained cyclists.
|<font color="#0000FF"><u>[http://www.ncbi.nlm.nih.gov/pubmed/7674870 Med Sci Sports Exerc. 1995 May;27(5):668-73.]</u></font>
|align = "center"|1995-05-01
|1. Twenty male cyclists (ages 23-29) with maximal aerobic power (VO2max) between 58 and 81 ml.min-1.kg-1 were randomly divided into BRIEF (N = 10) and PROLONGED (N = 10) groups. <br>2. One hour after drinking a beverage with or without choline bitartrate (2.43 g), cyclists began riding at a power output equivalent to approximately 150% (BRIEF) and 70% (PROLONGED) of VO2max at a cadence of 80-90 rpm. <br>3.Time to exhaustion, indirect calorimetry and serum choline, lactate, and glucose were measured.
|Trained cyclists do not deplete choline during supramaximal brief or prolonged submaximal exercise, nor do they benefit from choline supplementation to delay fatigue under given conditions.
|-
|}
*'''[[Media:cbt Non_Patent Analysis sheet.xls|Click here for Scientific Literature Analysis spread sheet]]'''
==Dashboard==
* Click at this link for '''[http://client.dolcera.com/dashboard/dashboard.html?workfile_id=554 Dashboard]'''
