BIOSIS / 2004:316145

AN

    2004:316145  BIOSIS

DN

    PREV200400316750

TI

    In vitro SAR of (5-(2H)-isoxazolonyl) ureas, potent inhibitors of
    hormone-sensitive lipase. 

AU

    Lowe, Derek B. [Reprint Author]; Magnuson, Steven; Qi, Ning; Campbell,
    Ann-Marie; Cook, James; Hong, Zhenqiu; Wang, Ming; Rodriguez, Mareli;
    Achebe, Furahi; Kluender, Harold; Wong, Wai C.; Bullock, William H.;
    Salhanick, Arthur I.; Witman-Jones, Terri; Bowling, Mary E.; Keiper,
    Christine; Clairmont, Kevin B.

CS

    Dept Chem, Bayer Res Ctr, 400 Morgan Lane, W Haven, CT, 06516, USA
    derek.lowe.b@bayer.com

SO

    Bioorganic & Medicinal Chemistry Letters, (June 21 2004) Vol. 14, No. 12,
    pp. 3155-3159. print. 
    CODEN: BMCLE8. ISSN: 0960-894X. 

DT

    Article

LA

    English

ED

    Entered STN: 15 Jul 2004
    Last Updated on STN: 15 Jul 2004

AB

    A series of (5-(2H)-isoxazolonyl) ureas were developed as nanomolar
    inhibitors of hormone-sensitive lipase, an enzyme of potential
    importance in the treatment of diabetes.  Copyright 2004 Elsevier Ltd.
    All rights reserved.

CC

    Pathology - Therapy   12512
    Metabolism - Metabolic disorders   13020
    Endocrine - Pancreas   17008
    Pharmacology - General   22002

IT

    Major Concepts
       Pharmacology

IT

    Diseases
       diabetes: endocrine disease/pancreas, metabolic disease
       Diabetes Mellitus (MeSH)

IT

    Chemicals & Biochemicals
       (5-(2H)-isoxazolonyl) ureas: hormone-sensitive lipase inhibitors,
       in vitro structure-activity relationships; hormone-sensitive lipase

IT

    Miscellaneous Descriptors
       lipolysis

RN

    9001-62-1 (hormone-sensitive lipase)