Changes

More details on GSK-3

669 bytes added, 11:22, 14 July 2006
/* Beta-catenin */
721 SGGYGQDALG MDPMMEHEMG GHHPGADYPV DGLPDLGHAQ DLMDGLPPGD SNQLAWFDTD<br>
781 l
 
==Role of beta catenin==
 
* Stabilized β-catenin can induce new hair follicles and trichofolliculoma-like tumors in skin. [http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=154144#B33 source]
* Follicular (hair) and epidermal stem cells are located in the bulge region.
* In the absence of β-catenin, stem cells can differentiate into the epidermal lineage but not into the hair follicular lineage. [http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=154144 source]
* In a research, expression of stabilized β-catenin in the epidermis of transgenic mice resulted in hair follicle morphogenesis. [http://www.biomedcentral.com/1471-2121/7/4#B8 source]
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