While the precise mechanism of action remains poorly understood, there are multiple antitumor effects of IFN-{alpha}. These include a direct antiproliferative effect, the enhancement of natural killer cell activity, and the upregulation of tumor antigens and/or HLA class I and class II antigens. Initial phase II clinical studies with IFN-{alpha} in metastatic melanoma showed response rates in the 10%–20% range [4, 5]. These response rates, while encouraging, were not significant enough to lead to its widespread use in the treatment of metastatic melanoma. [http://theoncologist.alphamedpress.org/cgi/content/full/8/5/451 Source]
==Interactive Taxonomy==
<mm>[[Interferon_For_the_treatment_Of_Melanoma.mm|1000px]]</mm>
==Concept Table==