Changes

* "Medication for men plagued by hair loss has become a topic of interest in Japan since a drug company began marketing it at the end of last year." March 5th, 2006 – [http://stophair.setupmyblog.com/?p=55Source] * "An increasing number of companies are apparently turning the Chinese fear of a bald spot into big bucks with some doing so well they are branching out into other countries." February 16, 2006 – [http://stophair.setupmyblog.com/Source] * "There is something in the air, or should we say in the hair, these days. Scientific research into hair loss remedies has never been more active or more exciting." June 7, 2006 - [http://www.prnewswire.com/cgi-bin/stories.pl?ACCT=109&STORY=/www/story/06-07-2005/0003821470&EDATE=Source]<br><br> == Alopecia IPMap == [http://www.dolcera.com/client/ds94x0s90akq9d7xb402fm/hairloss_map.htm Dolcera IPMap for Alopecia]<br>

* Hair grows everywhere on the body with the exception of the lips, eyelids, the palms of the hands and soles of the feet.

* Hair Structure - [http://www.pg.com/science/haircare/hair_twh_12.htmSource]* Hair Cycle - [http://www.follicle.com/hair-structure-life-cycle.htmlSource] [[Image:Hairbasics.jpg|thumb|center|500px400px|Structure of Hair root and Hair bulb]]

* Decreased Decrease in growth of the hair * Increased Increase in shedding of the hair * Breakage of hairs hair

[[Image:Facts.jpg|thumb|right|400px250px|Survey results from Japan]]Both men and women lose hair for similar reasons. Hair loss in men is often more dramatic, and follows a specific pattern of loss, one of which has been termed '''“Male Pattern Baldness"''' or '''"Androgenetic Alopecia"'''.

=== Types of alopecia=== * '''Alopecia Areata (AA):''' Used to describe hair Hair loss occurring in patches anywhere on the body.* '''Alopecia Totalis (AT):''' Total loss of the hair on the scalp.* '''Alopecia Universalis (AU):''' Total loss of all hair on the body.* '''Alopecia Barbae:''' Loss of facial hair (for a man) especially in the beard area.* '''Alopecia Mucinosa:''' A type of alopecia which results in scaley patches.* '''Androgenetic Alopecia (AGA)''': Also known as male pattern baldness. It is a thinning of the hair to an almost transparent state, in both men or women. It is thought to be a hereditary form of hair loss.* '''Traction Alopecia:''' Traction alopecia is usually due to excessive pulling or tension on hair shafts as a result of certain hair styles. It is seen more often in women, particularly those of East Indian and Afro-Caribbean origin. Hair loss depends on the way the hair is being pulled. Prolonged traction alopecia can stop new hair follicles from developing and lead leads to permanent hair loss.* '''Anagen Effluvium:''' This hair loss is generally caused by chemicals such as those used to treat cancer. Initially it causes patchy hair loss, which often then becomes leads to total hair loss. The good news is that when you stop using these chemicals the hair normally grows back (usually about 6 months later). Other drugs also can cause hair loss. Many medicines used to treat even common diseases can cause hair loss.* '''Scarring Alopecia:''' A form of alopecia which leaves scarring on the area of hair loss.* '''Telogen Effluvium:''' A form of hair loss where more than normal amounts numbers of hair fall out. There is a general 'thinning' of the hair. Unlike some other hair and scalp conditions, it is temporary and the hair growth usually recovers. ([http://www.alopeciaonline.org.uk/about/types.asp sourceSource])

* Gradual Onset.onset* Transition from large, thick, pigmented terminal hairs to thinner, shorter, indeterminate hairs and finally to short, wispy, nonpigmented non-pigmented vellus hairs in the involved areas.* Characterised Characterized by a receding hairline and/or hair loss on the top of the head.

== Goals ==The goal of this report is to: * Summarize IP activity over the years* Identify major players* Conduct patent analysisa) Compositionb) Naturec) Action* Technology mapping based on patent anlysis elements == IP activity over years ==

[[Image:players.jpg|thumb|left|400px500px|Assignees with more than 20 patents ]][[Image:players1.jpg|thumb|center|400px500px|Assignees with fewer than 20 patents ]]<br>

== Approach and Methodalogy Taxonomy ==

* A broad search was conducted on hair loss patents[[Image:Alopecia toxonomy.jpg|thumb|center|800px]]* Patent information was sourced through SIP.* A set == Interactive Taxonomy ==''Use the mouse(click and drag/scroll up or down/click on nodes) to explore nodes in the detailed taxonomy'' <br>''Click on the red arrow on the side of patents was selected a node name to view the content for analysisthat particular node in the dashboard''  <mm>[[Map12.mm]]</mm>

* Anti-androgens(Finasteride) [http://www.emedicine.com/DERM/topic21.htm source]* Minoxidil Vasodilators (as vasodilatorsMinoxidil)[http://www.emedicine.com/DERM/topic21.htm source]* Double action (Anti-androgen + MindoxidilVasodilator)

|bgcolor=LightCyan|[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060009430%22.PGNR.&OS=DN/20060009430&RS=DN/20060009430 [US20060009430]]

|bgcolor=LightCyan|Acts as androgen receptor modulators modulator and blocks formation of DHT.

|bgcolor=LightCyan|Inhibit Inhibits synthesis of bradykinin receptors or compounds by binding to B2 receptor

* A thick network of tiny veins and arteries lines line the outer wall of the follicle. Blood pumps through the bulb and hair via this network.

'''How does Minoxidal Minoxidil treat hair loss?'''* Minoxidal Minoxidil is applied to the scalp topically, where it dilates blood vessels in the scalp and sustains the hair follicles for longer period of time.* Minoxidil is thought to have a direct mitogenic effect on epidermal cells, as has been observed both in vitro and in vivo. Though the mechanism of its action for causing cell proliferation is not very clear, minoxidil is thought to prevent intracellular calcium entry. Calcium normally enhances epidermal growth factors to inhibit hair growth, and Minoxidil by getting converted to minoxidil sulfate acts as a potassium channel agonist and enhances potassium ion permeability to prevent calcium ions from entering into cells.([http://www.hairtransplantadvice.com/medical-hair-restoration.php sourceSource])

==== Functions of Monoxidil Vasodilators ====

==== IP Map for Minoxidil Vasodilators ====

=== Double action (Anti-androgen + MinoxidilVasodilator) ===* Combination of Minoxidil Vasodilator + Anti-androgen (double action) composition for effective treatment of Male-Pattern Baldness.

* Anti-androgen only prevent prevents binding of DHT to androgen receptors. However, the effects of improper oxygen and nutrient supply to the brain due to vasocontriction still remains and gradually causes hair loss.

'''What is the problem with using only Minoxidal Vasodilator (or Minoxidil only) therapy?'''* Vasodilator or Minoxidil-based products are generally not effective in stopping hair loss as minoxidil does vasodilators (or Minoxidil) do not block the harmful effects of DHT in the scalp and hair follicles. * Vasodilators or Minoxidil simply dilates dilate blood vessels in the scalp. However, the harmful DHT is still being gets produced in the body and still getting into , enters the scalp and hair follicles and causing eventual hair loss.

'''How is the combination of Anti-androgens and Vasodilator (or Minoxidil ) effective?'''

* Vasodilators like Minoxidil causes cause vasodilation and therefore improves improve supply of oxygen and nutrients to the hair follicle and roots.

==== Functions of (Anti-androgen + MinoxidilVasodilators) ==== [http://www.revivogen.com/revivogen/work.html Anti-androgen ]and [http://www.xandrox.net/articles/article01.htm Minoxidil][[Image:Doubleaction1.jpg|thumb|center|500px|Functions of (Anti-androgen + MinoxidilVasodilators)]]

==== IP Map for (Anti-androgen + MinoxidilVasodilators) ====

|bgcolor=LightCyan|Testosterone blocker or vascular toner (Flutamide, cyproterone acetate, spironolactone, progesterone, or analogs or derivatives) and minoxidil mixed along with non-retinoid penetration enhance enhancer and sunscreen

=== Hair matrix cell activator ===

==== Functions of Hair matrix cell activator === =[http://www.ijdb.ehu.es/fullaccess/fulltext.04023/ft163.pdf Hair matrix cell activator]

==== IP Map for Hair matrix cell activator ====

!width="75100" bgcolor=DodgerBlue|'''Nature'''!width="500200" bgcolor=DodgerBlue|'''Composition'''

|- style="height:100px50px"

|- style="height:100px50px"

|bgcolor=LightCyan|Reducing the expression of MMPs (Metalloproteases) in the scalp - slow slows down or inhibit inhibits the degradation of the perifollicular matrix (extracellular matrix surround surrounding the hair follicle)

== Technology mapping based on patents anlyzed analyzed ==

!width="50120" bgcolor=DodgerBlue|'''Year'''!width="100200" bgcolor=DodgerBlue|'''Organic Compound'''!width="100200" bgcolor=DodgerBlue|'''Natural extracts''' !width="100200" bgcolor=DodgerBlue|'''Peptides'''!width="100200" bgcolor=DodgerBlue|'''Nucleotides'''!width="100200" bgcolor=DodgerBlue|'''Natural extract + Organic comp'''

 === Focus of patents ===

!width="600800" bgcolor=DodgerBlue|'''Focus of patents'''!width="120150" bgcolor=DodgerBlue|'''Patent no.'''!width="60100" bgcolor=DodgerBlue|'''Rec. no.'''

 === Distribution of patents ===

==== By patent types ====

==== By key ingredients ====

==== By target disease ====

==== Key ingredients vs. Target disease ====

==== Target species ====

 ==== Mode of administration ====

==== Product type vs. Product form ====

==== Patents by target diseases ====

!width="600800" bgcolor=DodgerBlue|'''Target disease/ disorder'''!width="20150" bgcolor=DodgerBlue|'''Patent no.'''!width="20150" bgcolor=DodgerBlue|'''Rec. no.'''

=== Signaling Pathway = [[List of patents]] ====== Pathways and linkages == === Pathways associated with hair matrix cell activation=== 

 [[Image:Slide1.GIF|thumb|center|700px|Alopecia pathways]] ==== Players of Wnt WNT inhibition Pathway == == [[Image:wnt.jpg|thumb|right|600px200 px|Wnt inhibition]]

!width="70150" bgcolor=DodgerBlue|'''Patent no.'''!width="20200" bgcolor=DodgerBlue|'''Key compound'''!width="70200" bgcolor=DodgerBlue|'''Players of inhibition'''

|bgcolor=LightCyan|GSK3, βß-catenin

|bgcolor=LightCyan|βß-catenin, GSK3, Wnt

|bgcolor=LightCyan|βß-catenin

|bgcolor=LightCyan|αa-catenin, βß-catenin

|bgcolor=LightCyan|βß-catenin

|bgcolor=LightCyan|βß-catenin

* Pyrazoles are produced synthetically through the reaction of αa,βß-unsaturated aldehydes with hydrazine and subsequent dehydrogenation

==== GSK3 inhibition by pyrazole compounds ====

!width="100350"|[http://patft1.uspto.gov/netacgi/nph-Parser?TERM1=6989385+&Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=0&f=S&l=50 US6989385]

!width="100350"|[http://patft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=6664247.PN.&OS=PN/6664247&RS=PN/6664247 US6664247]

!width="100350"|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2005012256&F=0 WO2005012256]

==== Inhibition by amine derivatives ====

'''[[Derivatives of pyrimidine-pyrazole amine disclosed in the US6989385 patent:''']]

'''[[Derivatives of pyrimidine-pyrazole amine disclosed in the US7008948 patent:''']]

'''[[Derivatives of pyrimidine-pyrazole amine disclosed in the US6977262 patent:''']]

'''[[Derivatives of pyrimidine-pyrazole amine disclosed in the US6664247 patent:''']]

'''[[Derivatives of pyrimidine-pyrazole amine disclosed in the US2004224944 patent:''' * [2-(2-Chloro-phenyl)-6,7-dihydro-5H-cyclopentapyrimidin-4-yl]-(5,7-difluoro-1H-indazol-3-yl)-amine * (1H-Indazol-3-yl)-[2-(2-trifluoromethyl-phenyl)-5,6,7,8,9,10-hexahydro-cyclooctapyrimidin-4-yl]-amine * (7-Fluoro-1H-indazol-3-yl)-[2-(2-trifluoromethyl-phenyl)-5,6,7,8,9,10-hexahydro-cyclooctapyrimidin-4-yl]-amine * (5,7-Difluoro-1H-indazol-3-yl)-[2-(2-trifluoromethyl-phenyl)-5,6,7,8,9,10-hexahydro-cyclooctapyrimidin-4-yl]-amine * [6-Cyclohexyl-2-(2-trifluoromethyl-phenyl)-pyrimidin-4-yl]-(1H-indazol-3-yl)-amine * [6-(2-Fluoro-phenyl)-2-(2-trifluoromethyl-phenyl)-pyrimidin-4-yl]-(1H-indazol-3-yl)-amine * (6-Fluoro-1H-indazol-3-yl)-[2-(2-trifluoromethyl-phenyl)-quinazolin-4-yl]-amine * 3-[2-(2-Trifluoromethyl-phenyl)-quinazolin-4-ylamino]-1H-indazole-5-carboxylic acid methyl ster * (5-Methyl-2H-pyrazol-3-yl)-[2-(2-naphthyl-1-yl)-quinazolin-4-yl]-* [2-(2-Chloro-phenyl)-pyrido[2,3-d]pyrimidin-4-yl]-(7-fluoro-1H-indazol-3-yl)-amine * [2-(2-Chloro-phenyl)-pyrido[2,3-d]pyrimidin-4-yl]-(5-fluoro-1H-indazol-3-yl)-amine === Other derivates for alopecia ===[[Image:other derivates.jpeg]] == Inhibition of 5- - reductase by Finasteride ==[[Image:5-alpha-reductase inhibition.jpeg]] === Structure-Activity Relationships(SARs) ===[[Image:SAR_map.gif]]     

==== GSK-3 InhibitionMechanism - Phosphorylation====* ''GSK-3 inhibition targets treatment of chemotherapy-induced alopecia'' [http://www.biomedcentral.com/1471-2199/5/15 source]

== Questions Dolcera Answers = Pathway associated with anti-androgen ===

'''What’s hot?'''* Dihydrotestosterone * What compositions/ approaches are the most promising?* Formed by peripheral conversion of testosterone by 5-alpha reductase* What can I license?* Binds to androgen receptor on susceptible hair follicles* Can you map blockbuster products Hormone-receptor complex activates genes responsible for gradual transformation of large terminal follicles to miniaturized (progressive diminution of hair shaft diameter and length in response to their patents?systemic androgens) follicles

'''Any hints === Pathway associated with Minoxidil (vasodilators) ===Minoxidil is a well know drug used for research?'''the treatment of alopecia. A co-relation between Sesquiterpene lactone (Helenalin) produced from Arnica montana and Minoxidil is illustrated in the figure below. Arnica montana, a Vasodilator, acts on the NO/cGMP Pathway through T-cells, B-cells and epithelial cells & abrogates kappa B-driven gene expression.* Are there any combinations I could develop?[[image:vasodiator-rev.jpg|800 px|center]]

'''What should I do in this geography?'''== Alopecia IPMap == * What are my competitors up to in this geography?* What are my strengths[http://www.dolcera.com/client/d8r3/ weaknesses here?hairloss_map.htm Dolcera IPMap for Alopecia]

  == Patent activity in China =====Treatment approaches==={|border="2" cellspacing="0" cellpadding="4" width="100%"|align = "center"|'''How do Treatment approach'''|align = "center"|'''Patent number'''|align = "center"|'''Priority year'''|align = "center"|'''Assignee/Inventor'''|-|rowspan = "7"|Vasodilators|[http://search.sipo.gov.cn/sipo/zljs/hyjs-yx-new.jsp?recid=CN200510107497.8&leixin=fmzl&title=治疗瘀血阻滞型脱发的中草药汤剂及制备方法&ipc=A61K36/804(2006.01)I play defenseCN1772105]|2005|叶明伟|-|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=CN1772139&F=0 CN1772139]|2005|王亚杰|-|[http://search.sipo.gov.cn/sipo/zljs/hyjs-yx-new.jsp?recid=CN03139861.8&leixin=fmzl&title=一种可用于治疗脱发、白发的天然中草药提取组合物及应用&ipc=A61K35/78 CN1569080]|2003|谈汝标|-|[http://search.sipo.gov.cn/sipo/zljs/hyjs-yx-new.jsp?recid=CN02155404.8&leixin=fmzl&title=毛囊激活液&ipc=A61K35/78 CN1506103]|2002|赵章光|-|[http://search.sipo.gov.cn/sipo/zljs/hyjs-yx-new.jsp?recid=CN01127395.X&leixin=fmzl&title=一种止脱生发药物及其制备方法&ipc=A61K35/78 CN1403100]|2001|范希田|-|[http://search.sipo.gov.cn/sipo/zljs/hyjs-yx-new.jsp?recid=CN96116925.7&leixin=fmzl&title=免洗养发生发香波&ipc=C11D3/48 CN1165181]|1996|殷国健|-|[http://search.sipo.gov.cn/sipo/zljs/hyjs-yx-new.jsp?recid=CN88103853.9&leixin=fmzl&title=一种通络生发香波&ipc=A61K7/06 CN1031022]|1988|天津市轻工业化学研究所|-|Hair matrix activator|[http://search.sipo.gov.cn/sipo/zljs/hyjs-yx-new.jsp?recid=CN02111941.4&leixin=fmzl&title=一种含中西药复方的育发剂&ipc=A61K7/06 CN1463693]|2002|朱静建|-|Anti-androgen <nowiki>+</nowiki> Vasodilator|[http://search.sipo.gov.cn/sipo/zljs/hyjs-yx-new.jsp?recid=CN96109964.X&leixin=fmzl&title=一种治疗脂溢性脱发的高效低副作用外用药物&ipc=A61K35/78 CN1150043]|1996|梅晓春|-|} === Details of treatment approaches=== {|border="2" cellspacing="0" cellpadding="4" width="100%" align="left"|align = "center"|'''Patent number'''* What should my blocking|align = "center"|'''Patent title'''|align = "center"|'''Treatment approach'''|align = "center"|'''Composition nature'''|align = "center"|'''Composition'''|align = "center"|'''Composition action'''|-|align = "justify"|[http:/reactive strategies be/search.sipo.gov.cn/sipo/zljs/hyjs-yx-new.jsp?recid=CN200510107497.8&leixin=fmzl&title=治疗瘀血阻滞型脱发的中草药汤剂及制备方法&ipc=A61K36/804(2006.01)I CN1772105]<br>YE MINGWEI (CN)<br>叶明伟 (2005)|align = "justify"|Chinese herbal medicine decoction for treating blood stasis obstruction type alopecia and its prepn<br>治疗瘀血阻滞型脱发的中草药汤剂及制备方法|align = "justify"|Vasodilators|align = "justify"|Herbal extract|align = "justify"|Astragalus root, prepared rhizome of rehmannia, white peony root, angelica, peach kernel and sufflower|align = "justify"|Promote blood circulation|-|align = "justify"|[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=CN1772139&F=0 CN1772139<br>]WANG YAJIE (CN)<br>王亚杰 2005|align = "justify"|Alopecia areata treating medicine<br>一种治疗斑秃的药物|align = "justify"|Vasodilators|align = "justify"|Herbal extract|align = "justify"|Pinellia tuber, fleeceflower root, arborvitae seed, chickení s gizzard membrane, prepared rhizome of rehmannia, Poris cocos, Codonopsis pilosula, etc|align = "justify"|Promote blood circulation|-|align = "justify"|[http://search.sipo.gov.cn/sipo/zljs/hyjs-yx-new.jsp?recid=CN03139861.8&leixin=fmzl&title=一种可用于治疗脱发、白发的天然中草药提取组合物及应用&ipc=A61K35/78 CN1569080]<br>TAN RUBIAO (CN)<br>谈汝标 2003|align = "justify"|Natural Chinese herb composition for treating alopecia and leucotrichia and its application<br>一种可用于治疗脱发、白发的天然中草药提取组合物及应用|align = "justify"|Vasodilators|align = "justify"|Herbal extract|align = "justify"|Ginger, Cinnamomum cassia, myrrh, clove, mace nutmeg, Loranthus mulberry mistletoe, rhizoma dioscoreae, ligustrum japonicum, drynaria, fleece-flower root, and black sesame seeds|align = "justify"|Enhances the hair growth and healthier hairs|-|align = "justify"|[http://search.sipo.gov.cn/sipo/zljs/hyjs-yx-new.jsp?recid=CN02111941.4&leixin=fmzl&title=一种含中西药复方的育发剂&ipc=A61K7/06 CN1463693]<br>朱静建 2002|Hair growing preparation containing compound of Chinese medicine and Western medicine<br>一种含中西药复方的育发剂|align = "justify"|Hair matrix activator|Mixture of Herbal extracts and western medicine|align = "justify"|Persimmon leaf, oriental arbor-vitae leaf, ginseng leaf, yellow qi, fruit of the glossy privet, polygonum multiflorum, Kudzu root, dry ginger; Plus：Minoxidil, Vitamins and derivative, cystine, serine, leucine.|align = "justify"|Better and faster hair growth|-|align = "justify"|[http://search.sipo.gov.cn/sipo/zljs/hyjs-yx-new.jsp?recid=CN02155404.8&leixin=fmzl&title=毛囊激活液&ipc=A61K35/78 CN1506103]<br>赵章光2002|align = "justify"|Hair follice activating liquid<br>毛囊激活液|align = "justify"|Vasodilators|align = "justify"|Herbal extract|align = "justify"|Ginseng, twists the stock blue, the licorice, the Sophora flavescens and hot peppers|align = "justify"|Activates the hair-follicle and enhances the hair growth.|-|align = "justify"|[http://search.sipo.gov.cn/sipo/zljs/hyjs-yx-new.jsp?recid=CN01127395.X&leixin=fmzl&title=一种止脱生发药物及其制备方法&ipc=A61K35/78 CN1403100]<br>范希田 2001|align = "justify"|Trichogen and its prepn<br>一种止脱生发药物及其制备方法|align = "justify"|Vasodilators|align = "justify"|Herbal extract|align = "justify"|Ginseng, ganoderma lucidum, Chinese rhubarb, polygonum multiflorum, Chinese prickly ash, ginger, grass seed|align = "justify"|Promote blood circulation and enhance hair growth|-|align = "justify"|[http://search.sipo.gov.cn/sipo/zljs/hyjs-yx-new.jsp?recid=CN96116925.7&leixin=fmzl&title=免洗养发生发香波&ipc=C11D3/48 CN1165181]<br>殷国健 1996|Washing free shampoo for nourishing and growing hair<br>免洗养发生发香波|align = "justify"|Vasodilator|Vitamin composition|align = "justify"|Vitamin P (Bioflavonoids), Vitamin B15, Vitamin B2, nicotinic acid, bromo—geramineum|align = "justify"|Stimulate hair growth|-|align = "justify"|[http://search.sipo.gov.cn/sipo/zljs/hyjs-yx-new.jsp?recid=CN96109964.X&leixin=fmzl&title=一种治疗脂溢性脱发的高效低副作用外用药物&ipc=A61K35/78 CN1150043]<br>梅晓春 1996|Efficient low-side effect external use medicine for curing seborrheic baldness<br>一种治疗脂溢性脱发的高效低副作用外用药物|align = "justify"|Anti-androgen <nowiki>+</nowiki> Vasodilator|Mixture of Herbal extracts and organic compounds|align = "justify"|Polygonum multiflorum, Ligustrum lucidum, Morus alba, Rehmannia glutinosa, Eclipta prostrata, Saliva miltiorrhiza, Carthamus tinctorius, Cnidium monnieri, Sophora flavescens, Dictamnus dasycarpus, Kochia scoparia, and antioxidants|align = "justify"|Inhibit the excess secretion of the sebaceous glands, increase the blood circulation on scalp and enhance the hair growth|-|align = "justify"|[http://search.sipo.gov.cn/sipo/zljs/hyjs-yx-new.jsp?recid=CN88103853.9&leixin=fmzl&title=一种通络生发香波&ipc=A61K7/06 CN1031022]<br>天津市轻工业化学研究所 1988|Channel-stimulating and hair-growing hair shampoo<br>一种通络生发香波|align = "justify"|Vasodilators|Herbal extract <nowiki>+</nowiki> detergent|align = "justify"|<font color="#454545">Herbal extracts, Penetration media, Detergents.</font>|align = "justify"|Increases the blood circulation under the scalp, reduces the hair los|-|}<br clear="all">  ==<span style="color:#C41E3A">Like this report?</span>==<p align="center"> '''This is only a sample report with brief analysis''' <br>'''Dolcera can provide a comprehensive report customized to your needs'''</p>{|border="2" cellspacing="0" cellpadding="4" align="center" "|style="background:lightgrey" align = "center" colspan = "3"|'''[mailto:info@dolcera.com <span style="color:#0047AB">Buy the customized Alopecia report from Dolcera</span>]''' |-| align = "center"| [http://www.dolcera.com/website_prod/services/ip-patent-analytics-services Patent Analytics Services]|align = "center"| [http://www.dolcera.com/website_prod/services/business-research-services Market Research Services]|align = "center"| [http://www.dolcera.com/website_prod/tools/patent-dashboard Purchase Patent Dashboard]|-|align = "center"| [http://www.dolcera.com/website_prod/services/ip-patent-analytics-services/patent-search/patent-landscapes Patent Landscape Services]|align = "center"| [http://www.dolcera.com/website_prod/research-processes Dolcera Processes]|align = "center"| [http://www.dolcera.com/website_prod/industries Industry Focus]|-|align = "center"| [http://www.dolcera.com/website_prod/services/ip-patent-analytics-services/patent-search/patent-landscapes Patent Search Services]|align = "center"| [http://www.dolcera.com/website_prod/services/ip-patent-analytics-services/alerts-and-updates Patent Alerting Services]|align = "center"| [http://www.dolcera.com/website_prod/tools Dolcera Tools]|-|}<br>

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