AN
1998:497819 BIOSIS
DN
PREV199800497819
TI
Neuro-humoral regulation of lipolysis: Physiological and pathological aspects.
AU
Lafontan, Max [Reprint author]; Langin, Dominique
CS
Inserm U. 317, Inst. Louis-Bugnard, Univ. Paul-Sabatier, CHU Rangueil, Batiment L3, 31403 Toulouse Cedex 4, France
SO
M-S (Medecine Sciences), (Aug.-Sept., 1998) Vol. 14, No. 8-9, pp. 865-876. print. ISSN: 0767-0974.
DT
Article General Review; (Literature Review)
LA
French
ED
Entered STN: 18 Nov 1998 Last Updated on STN: 18 Nov 1998
AB
Lipolysis in white fat cells plays a central role in the regulation of energy balance. Triacylglycerols (TAG) stored in the adipocytes are hydrolysed consecutively to hormone sensitive lipase (HSL) activation during the stimulation of lipolysis. HSL catalyses the hydrolysis of TAG to diacylglycerol and then to monoacylglycerol. The hydrolysis of the monoacylglycerol-fatty acid bond is assured by a monoacylglycerol lipase. HSL is phosphorylated by the cAMP-dependent protein kinase. Genomic organization and functional domains of rodent and human hormone-sensitive lipase have recently been studied. Acute regulation of HSL by catecholamines and insulin is well documented. Non-esterified fatty acids and glycerol released by adipose tissue are taken up by other tissues where they are metabolized. The local blood flow in adipose tissue modulates the mobilization and the re-utilization of fatty acids. Local blood flow and lipolysis are regulated by hormonal factors and influenced by a number of physiological factors such as diets, exercise, aging and sex. Insulin and catecholamines are the major hormonal regulators of lipolysis. Their control of lipolysis is subjected to variations according to the anatomical localization of adipose tissue deposits. In human, lipolysis differs in visceral and subcutaneous deposits. Insulin exerts its antilipolytic action through the stimulation of adipocyte phosphodiesterase 3B. Four adrenoceptor subtypes are involved in the adrenergic regulation of white and brown fat cell lipolysis. The control of adenylyl cyclase activity involves stimulatory beta1-, beta2- and beta3-adrenergic receptors and inhibitory alpha2-adrenoceptors. Many clinical disorders are accompanied by alteration in adipocyte lipolysis. Alteration of hormone-sensitive lipase activity and of catecholamine-induced lipolysis have been reported in obesity, familial combined hyperlipidemia, insulin resistance syndrome and diabetes. Changes in beta- and alpha2-adrenoceptor ratios and function as well as impairment of HSL function have been proposed to explain the lipolytic disturbances.
CC
Metabolism - General metabolism and metabolic pathways 13002 Nervous system - General and methods 20501
IT
Major Concepts Metabolism
IT
Parts, Structures, & Systems of Organisms adipocyte, lipolytic disorders
IT
Diseases obesity: nutritional disease Obesity (MeSH)
IT
Chemicals & Biochemicals hormone-sensitive lipase; triacylglycerols: hydrolysis
IT Miscellaneous Descriptors
clinical applications; lipolysis: neurohumoral regulation; pathophysiology; physiology
ORGN
Classifier Hominidae 86215 Super Taxa Primates; Mammalia; Vertebrata; Chordata; Animalia Organism Name human: patient Taxa Notes Animals, Chordates, Humans, Mammals, Primates, Vertebrates
ORGN
Classifier Rodentia 86265 Super Taxa Mammalia; Vertebrata; Chordata; Animalia Organism Name rodent: animal model Taxa Notes Animals, Chordates, Mammals, Nonhuman Vertebrates, Nonhuman Mammals, Rodents, Vertebrates
RN
9001-62-1 (LIPASE)