AN
2004:279615 BIOSIS
DN
PREV200400277461
TI
Hormone-sensitive lipase - New roles for an old enzyme.
AU
Yeaman, Stephen J. [Reprint Author]
CS
Sch MedSch Cell & Mol Biosci, Univ Newcastle Upon Tyne, Newcastle Upon
Tyne, Tyne & Wear, NE2 4HH, England
s.j.yeaman@ncl.ac.uk
SO
Biochemical Journal, (April 1 2004) Vol. 379, No. Part 1, pp. 11-22.
print.
ISSN: 0264-6021.
DT
Article
General Review; (Literature Review)
LA
English
ED
Entered STN: 9 Jun 2004
Last Updated on STN: 9 Jun 2004
AB
Although described initially as an intracellular adipocyte-specific
triacylglycerol lipase. it is now clear that HSL (hormone-sensitive
lipase) is expressed in Multiple tissues and plays a number of roles in
lipid metabolism. including that of a neutral cholesteryl ester hydrolase.
The major isoform is a single polypeptide with a moleclar mass of approx.
84 kDa and which comprises three major domains: a catalytic domain. a
regulatory domain encoding several phosphorylation sites and an N-terminal
domain involved in protein-protein and protein-lipid interactions. The
activity of HSL is regulated acutely by several mechanisms, including
reversible phosphorylation by a number of different protein kinases,
translocation to different sites within the cell and interaction with a
number of proteins, some of which may serve to direct the inhibitory
products of HSL away from the protein. It is also apparent from work
with HSL null mice that more than one enzyme species may be classified
as a hormone-sensitive lipase. The possible presence of HSL in
macrophages remains controversial, and the role of the protein in
pancreatic beta-cells has yet to be fully elucidated. Altered expression
of HSL in different cell types may be associated with a number of
pathological states, including obesity, atherosclerosis and Type II
diabetes.
CC
Cytology - General 02502
Cytology - Animal 02506
Biochemistry studies - Sterols and steroids 10067
Enzymes - General and comparative studies: coenzymes 10802
Metabolism - General metabolism and metabolic pathways 13002
Blood - Blood and lymph studies 15002
Blood - Blood cell studies 15004
Endocrine - General 17002
Immunology - General and methods 34502
IT
Major Concepts
Cell Biology; Endocrine System (Chemical Coordination and Homeostasis);
Enzymology (Biochemistry and Molecular Biophysics); Metabolism
IT
Parts, Structures, & Systems of Organisms
beta-cell: endocrine system; macrophage: blood and lymphatics, immune
system
IT
Chemicals & Biochemicals
cholesterol: metabolism; hormone-sensitive lipase; perilipin;
protein kinase [EC 2.7.1.37]
IT
Miscellaneous Descriptors
lipolysis; phosphorylation; protein-lipid interactions; protein-protein
interactions
ORGN
Classifier
Muridae 86375
Super Taxa
Rodentia; Mammalia; Vertebrata; Chordata; Animalia
Organism Name
mouse (common)
Taxa Notes
Animals, Chordates, Mammals, Nonhuman Vertebrates, Nonhuman Mammals,
Rodents, Vertebrates
RN
57-88-5 (cholesterol)
9001-62-1 (hormone-sensitive lipase)
9026-43-1Q (protein kinase)
80449-02-1Q (protein kinase)
134549-83-0Q (protein kinase)
372092-80-3Q (protein kinase)
9026-43-1 (protein kinase)
9026-43-1Q (EC 2.7.1.37)
80449-02-1Q (EC 2.7.1.37)
134549-83-0Q (EC 2.7.1.37)
372092-80-3Q (EC 2.7.1.37)
9026-43-1 (EC 2.7.1.37)