Difference between revisions of "Choline Bitartarate"

Latest revision as of 02:48, 27 July 2015

Overview

Choline is an organic compound, usually grouped within the Vitamin B complex. There are eight B vitamins in the Vitamin B complex family. Although each performs a different function in the body, they all work together to maintain good health.

Structure of Choline bitartrate Source

Choline is available in various forms namely, choline bitartrate, choline citrate,choline chloride and others.
Choline Bitartrate (L(+) choline bitartrate) is a colorless or white crystal powder, which is a water-soluble part of the B Vitamin family. Its IUPAC Name: 2-hydroxyethyl(trimethyl)azanium; (2R,3R)-2,3,4-trihydroxy-4-oxobutanoate and CAS Registry Number is : 87-67-2. Source
The body needs B vitamins to manufacture neurotransmitters, chemicals that control alertness and mood by speeding nerve signals through the brain.
As B vitamins are water soluble, they are excreted in the urine and can be quickly depleted from the body. Only a small amount is stored in the body. Because of this, it is important that we take supplements to replenish these important vitamins in our body. Source

Choline bitartrate is an essential nutrient needed by the nervous system to produce acetylcholine. Acetylcholine is a neurotransmitter that facilitates the transmission of impulses between neurons. Source

Natural Source of Choline bitartrate: Egg yolk, peanuts, wheat germ, organ meats and legumes.

Health Benefits of Choline Bitartrate:

Being a product of vitamin, it can be applied to medicine, healthcare product and food.
It is a nutritious additive and fat remover, enhance fatty metabolism and eliminate the accumulation of fat in liver.
Influence muscle contractions, movement, coordination and enhance memory.
Involved in higher level brain functions like memory, thought and intellect.
Is vital to the structural integrity of cell walls, the production of amino acids and proteins and the metabolism of fats.
Aid in the treatment of Alzheimer’s Disease, manic depression and improve the symptoms of Parkinson’s Disease.

Deficiencies in B vitamins causes:

Depression or signs of decreased mental functioning.
Decrease cognitive function.

Intellectual Property

Search Strategy

Databases: USG USA EPA EPB WO JP DEG DEA DET DEU GBA FRA

Years: From 1836 - To April 18, 2009.

S.No	Concept	Scope	Search Query	Hits
1	Choline bitartarate	Full Spec.	((choline ADJ1 bitartarate) OR (choline ADJ1 bitartrate) OR (choline ADJ1 bi ADJ1 tartrate*) OR (2-Hydroxyethyl ADJ1 trimethyl ADJ1 ammonium ADJ1 bitartrate) OR ((2-Hydroxyethyl) ADJ1 trimethyl ADJ1 ammonium ADJ1 bitartrate) OR ((2-Hydroxyethyl)trimethylammonium ADJ1 bitartrate))	1016 hits
2	Food & beverage	Claims, Title or Abstract	(beverage* OR drink* OR juice* OR potion OR tonic OR spirit* OR (liquid ADJ1 refreshment) OR Tea OR milk OR coffee OR cocoa OR (liquid ADJ (formulation1 OR preparation1)) OR capsule* OR caplet* OR tablet* OR powder2 OR (Nutri ADJ supplement) OR Food OR Meal* OR composition OR (Nutrition* NEAR3 adjuvant* ) OR (food NEAR3 supplement) OR formula OR formulation)	3677912 hits
3		Combine	1AND 2	881 hits (Unique Records 444)

STN Search Strategy

=> FILE REGISTRY

=> UPLOAD STRUCTURE

L1

Cholinebitartrate

=> D L1

=> S L1 EXACT SAM

L2

=> D SCAN

=> S L1 EXACT FULL

L3

SET PLURAL ON PERM

SET ABBREVIATION ON PERM

SET SPELLINGS ON PERM

=> S L3 AND PATENT/DT

L4

=> S L3 NOT PATENT/DT

L5

=> D L4 IALL 1-

=> D L5 IALL 1-

=> LOGOFF Y

Analysis Taxonomy

IP activity over the years

Maximum number of patents have been filed in the year 2004.
Patents are published 18 months after application.

Graph showing IP Activity Over Years (Assignee versus earliest priority year)

Top Assignees

Council of Scientific & Industrial Research found to be the Top assignees with 3 patents.
For 2 patent / publications Assignee name is not available.

Graph showing Top assignee names

Patent Focus

Patents focusing on Composition.
Patents focusing on Methods.
Patents focusing on Composition and Methods.
Patents focusing on process of prepration.

Graph showing patents focusing on composition / methods or Both

Action of Choline bitartrate containing Compositions

Choline Bitartarate Patents categorised as per formulation

Product form	Patent/publication	Patent focus	Ingredients other than Choline Bitartarate	Application
Beverage / liquid / Drink	US20040005368A1	Composition and Method	1. At least one substance that enhance oxygen uptake such as Gingko A, Caffeine, Green Tea, L-pyroglutamate, Xanthinol nicotinate. 2. A protein supplement.	Used for weight loss.
	US20040191294A1	Composition, Method, Process of prepration	1. one or more omega 3 fatty acids. 2. milk or milk-based products .	lowers levels of cholesterol and triglycerides.
	US20060121158A1	Composition	1. A first ingredient comprising at least one of a polyol, a fiber or a combination thereof. 2. Second ingredient comprising calcium. 3. Third ingredient comprising at least one of flavanol, stimulant and antioxidant.	Used for weight management.
	US5626849A	Composition and Method	An essentially dry mixture of chromium, L-carnitine, gamma-linolenic acid, (-) hydroxycitric acid, inositol, antioxidants and herbs.	A dietary supplement to help facilitate weight loss
	US5904948A	Composition and Process of prepration	An protein component and a carbohydrate component.	Nutritional Supplement
	WO2006052231A1	Composition and Process of prepration	Sugar including the carbohydrates, fructose and maltodextrin, and electrolytes chromium, copper, potassium, magnesium, sodium, and citric acid.	Restoring human growth hormone.
	US20050171034A1	Composition and Method	Betaine, pyridoxal-5-phosphate, and N-acetyl-cysteine.	Promotes decrease of homocysteine levels in humans.
	US20060241077A1	Composition and Method	A uridine, an acyl derivative thereof, a uridine phosphate, uracil, or a salt thereof;	Ameliorating or inhibiting decline in memory or intelligence.
	US20070065456A1	Composition	Wasabia japonica, Silybum marianum, Cynara scolymus.	Nutritional supplement for a human diet.
	US20070248696A1	Composition and Method	Dimethylaminoethanol, cytidine 5’-diphosphocholine, turmeric extract, decaffeinated green tea extract, vitamin B1,B5, B6, B12,folic acid, Dimethylglycine, huperzine A, Griffonia simplicifolia extract and 1-phenylalanine.	Improves neuromuscular facilitation and enhances cognitive functions, such as memory and mental focus.
	US20080317868A1	Composition	An energy content, a protein fraction, a lipids fraction, a nucleotide fraction and a mineral fraction.	An anti-allergic infant formulation.
	US4497800A	Composition	A protein equivalent, a suitable lipid, a carbohydrate component , essential vitamins , minerals and an emulsion stabilizer.	Providing nourishment for a human patient in need of such nourishment .
	US4499076A	Composition	Essential amino acids, carbohydrates, fats, vitamins namely vitamin A, B1, B6, B12, C, D2, E, K1, calcium pantothenate, nicotinic acid amide, biotin, folic acid or choline bitartrate and minerals.	New elemental diets for liver diseases.
	US4837219A	Composition, Method, Process of prepration	L-Tyrosine, L-Phenylalanime, L-Leucine, Zinc (from Zinc Gluconate) and Copper (from Copper Gluconate).	A medication for Alzheimer’s disease.
	US5437880A	Composition	Digestible saccharide and a carotenoid.	A health drink
	WO1994015488A2	Composition	Carbohydrate, electrolyte, ammonia neutralizer, energy enhancer namely choline Bitartrate and others , antioxidant, neuromuscular function enhancer.
Foodstuff	US20050208191A1	Composition and Process of prepration	Whole wheat, Roasted (defatted) soy Peanut paste, Sesame seed paste Sesame seed , Wheat germ (roasted), Non fat dry milk, Sugar Powder, Liquid, Lecithin, Sodium Chloride, mmonium bicarbonate, vitamins and others.	Nutritious baked snack food with high protein content
Foodstuff	WO2005087018A1	Composition and Process of prepration	vegetable sources as wheat flout, roasted peanut paste, sesame seed, soybean flour and well balanced mixture of vitamins, minerals and others.	Food stuff for children and adult supplementing their nutritional requirement.

Choline Bitartarate containing compositions

Composition components matrix showing all the ingredients used along with Choline Bitartarate.

Beverage / liquid / Drink

Patent/Publication No.

Amino acids

Antioxidant

Carbohydrates / Sugars

Energy Source / Enhancer

Fatty Acids / A lipid Source

Herbal Extracts

Minerals

Proteins

Stimulant

Vitamins

Vegetable Sources

Others

US20040005368A1

x

Caffeine, Green Tea

Oxygen uptake enhancing substance.

US20040191294A1

x

Milk or milk-based products

US20060121158A1

x

Flavanol

US5626849A

x

gamma-linolenic acid

x

L-carnitine

US5904948A

Maltodextrin

x

Whey , milk or vegetable

x

WO2006052231A1

leucine, isoleucine, valine and arginine.

x

US20050171034A1

N-acetyl-cysteine

Alpha-lipoic acid

Zn

A, B, C, E

Betaine

US20060241077A1

Uridine or its derivative

US20070065456A1

Green tea extract

Taurine

Wasabia japonica, Silybum marianum and Cynara scolymus.

Mn, Se Zn

x

US20070248696A1

B1,B5, B6, B12,folic acid

Dimethylaminoethanol, cytidine 5’-diphosphocholine, turmeric extract, Green tea extract

US20080317868A1

x

Nucleotide fraction

US4497800A

x

US4499076A

Essential AA’S

x

Calcium pantothenate, nicotinic acid amide, biotin, folic acid

x

US4837219A

L-Tyrosine, L-Phenylalanime, L-Leucine

Zn and Cu

x

US5437880A

x

Digestible saccharide

A B, C, D, E and K .

Carotenoids

WO1994015488A2

x

choline Bitartrate

Neuromuscular function enhancer

Foodstuff

US20050208191A1

x

Fe, Zn, Cu, I ,

x

Sesame seed paste Sesame seed

Whole wheat, Roasted (defatted) soy Peanut paste, Wheat germ (roasted), Non fat dry milk

WO2005087018A1

x

Wheat flour, roasted peanut paste, sesame seed, soybean flour

x

Click here for Composition matrix showing all the ingredients used along with Choline Bitartarate.

Patent Analysis Sheets

Click here for all Patents spread sheet - Total count: 444

Click here for the complete Analysis spread sheet ON Target count: 22

Click here for list of ingredients that are in combination with Choline Bitartarate, obtained from Patents.

Scientific Literature Analysis

S.No.	Title	Citations	Publication Date	Results / Statastical data	Dolcera Summary
1	Effect of choline supplementation on fatigue in trained cyclists.	Med Sci Sports Exerc. 1995 May;27(5):668-73.	1995-05-01	1. Twenty male cyclists (ages 23-29) with maximal aerobic power (VO2max) between 58 and 81 ml.min-1.kg-1 were randomly divided into BRIEF (N = 10) and PROLONGED (N = 10) groups. 2. One hour after drinking a beverage with or without choline bitartrate (2.43 g), cyclists began riding at a power output equivalent to approximately 150% (BRIEF) and 70% (PROLONGED) of VO2max at a cadence of 80-90 rpm. 3.Time to exhaustion, indirect calorimetry and serum choline, lactate, and glucose were measured.	Trained cyclists do not deplete choline during supramaximal brief or prolonged submaximal exercise, nor do they benefit from choline supplementation to delay fatigue under given conditions.

Click here for Scientific Literature Analysis spread sheet

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Difference between revisions of "Choline Bitartarate"

Latest revision as of 02:48, 27 July 2015

Contents

Overview

Intellectual Property

Search Strategy

STN Search Strategy

Analysis Taxonomy

IP activity over the years

Top Assignees

Patent Focus

Action of Choline bitartrate containing Compositions

Choline Bitartarate Patents categorised as per formulation

Choline Bitartarate containing compositions

Patent Analysis Sheets

Scientific Literature Analysis

Dashboard

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Tools

@@ Line 52: / Line 52: @@
 |Combine
 |align = "center"|'''1AND 2'''
-|align = "center"|'''    881 hits (Unique Records 440)'''
+|align = "center"|'''    881 hits (Unique Records 444)'''
 |-
 |}
+===='''STN Search Strategy'''====
+=<nowiki>></nowiki>  FILE REGISTRY
+=<nowiki>></nowiki>  UPLOAD STRUCTURE
+'''L1'''
+[[Image:Cholinebitartrate.jpg|thumb|center|750px|'''Cholinebitartrate''']]
+=<nowiki>></nowiki> D L1
+=<nowiki>></nowiki> S L1 EXACT SAM
+'''L2'''
+=<nowiki>></nowiki> D SCAN
+=<nowiki>></nowiki> S L1 EXACT FULL
+'''L3'''
+SET PLURAL ON PERM
+SET ABBREVIATION ON PERM
+SET SPELLINGS ON PERM
+=<nowiki>></nowiki> S L3 AND PATENT/DT
+'''L4'''
+=<nowiki>></nowiki> S L3 NOT PATENT/DT
+'''L5'''
+=<nowiki>></nowiki> D L4 IALL 1-
+=<nowiki>></nowiki> D L5 IALL 1-
+=<nowiki>></nowiki> '''LOGOFF Y'''
+----
 ===Analysis Taxonomy===
@@ Line 81: / Line 127: @@
 ====Action of Choline bitartrate containing Compositions====
-<mm>[[Cbt_cadbury.mm]]</mm>
+<mm>[[Choline_bitartrate.mm]]</mm>
 ====Choline Bitartarate Patents categorised as per formulation====
@@ Line 186: / Line 232: @@
 ====Choline Bitartarate containing compositions====
-*[[Click here for Composition components matrix showing all the ingredients used along with Choline Bitartarate.]]
+*Composition components matrix showing all the ingredients used along with Choline Bitartarate.
 {|border="2" cellspacing="0" cellpadding="4" width="100%"
 |align = "center" bgcolor = "#FFCC99" colspan = "13"|<font size = "1">'''Beverage / liquid / Drink'''</font>
@@ Line 204: / Line 250: @@
 |align = "center" bgcolor = "#CCFFCC"|<font size = "1">'''Others'''</font>
 |-
-|<font size = "1">US20040005368A1</font>
+|<font color="#0000FF"><u>[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040005368%22.PGNR.&OS=DN/20040005368&RS=DN/20040005368 US20040005368A1]</u></font>
 |<font size = "1"> </font>
 |<font size = "1"> </font>
@@ Line 218: / Line 264: @@
 |<font size = "1">Oxygen uptake enhancing substance.</font>
 |-
-|<font size = "1">US20040191294A1</font>
+|<font color="#0000FF"><u>[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220040191294%22.PGNR.&OS=DN/20040191294&RS=DN/20040191294 US20040191294A1]</u></font>
 |<font size = "1"> </font>
 |<font size = "1"> </font>
@@ Line 232: / Line 278: @@
 |<font size = "1">Milk or milk-based products</font>
 |-
-|<font size = "1">US20060121158A1</font>
+|<font color="#0000FF"><u>[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060121158%22.PGNR.&OS=DN/20060121158&RS=DN/20060121158 US20060121158A1]</u></font>
 |<font size = "1"> </font>
 |align = "center"|<font size = "1">x</font>
@@ Line 246: / Line 292: @@
 |<font size = "1">Flavanol</font>
 |-
-|<font size = "1">US5626849A</font>
+|<font color="#0000FF"><u>[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5626849.PN.&OS=PN/5626849&RS=PN/5626849 US5626849A]</u></font>
 |<font size = "1"> </font>
 |align = "center"|<font size = "1">x</font>
@@ Line 260: / Line 306: @@
 |<font size = "1">L-carnitine</font>
 |-
-|<font size = "1">US5904948A</font>
+|<font color="#0000FF"><u>[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5904948.PN.&OS=PN/5904948&RS=PN/5904948 US5904948A]</u></font>
 |<font size = "1"> </font>
 |<font size = "1"> </font>
@@ Line 274: / Line 320: @@
 |<font size = "1"> </font>
 |-
-|<font size = "1">WO2006052231A1</font>
+|<font color="#0000FF"><u>[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2006052231&F=0 WO2006052231A1]</u></font>
 |<font size = "1">leucine, isoleucine, valine and arginine.</font>
 |<font size = "1"> </font>
@@ Line 288: / Line 334: @@
 |<font size = "1"> </font>
 |-
-|<font size = "1">US20050171034A1</font>
+|<font color="#0000FF"><u>[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050171034%22.PGNR.&OS=DN/20050171034&RS=DN/20050171034 US20050171034A1]</u></font>
 |<font size = "1">N-acetyl-cysteine</font>
 |<font size = "1">Alpha-lipoic acid</font>
@@ Line 302: / Line 348: @@
 |<font size = "1">Betaine</font>
 |-
-|<font size = "1">US20060241077A1</font>
+|<font color="#0000FF"><u>[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220060241077%22.PGNR.&OS=DN/20060241077&RS=DN/20060241077 US20060241077A1]</u></font>
 |<font size = "1"> </font>
 |<font size = "1"> </font>
@@ Line 316: / Line 362: @@
 |<font size = "1">Uridine or its derivative</font>
 |-
-|<font size = "1">US20070065456A1</font>
+|<font color="#0000FF"><u>[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070065456%22.PGNR.&OS=DN/20070065456&RS=DN/20070065456 US20070065456A1]</u></font>
 |<font size = "1"> </font>
 |<font size = "1">Green tea extract</font>
@@ Line 330: / Line 376: @@
 |align = "center"|<font size = "1">x</font>
 |-
-|<font size = "1">US20070248696A1</font>
+|<font color="#0000FF"><u>[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220070248696%22.PGNR.&OS=DN/20070248696&RS=DN/20070248696 US20070248696A1]</u></font>
 |<font size = "1"> </font>
 |<font size = "1"> </font>
@@ Line 344: / Line 390: @@
 |<font size = "1">Dimethylaminoethanol, cytidine 5<nowiki>’</nowiki>-diphosphocholine, turmeric extract, Green tea extract</font>
 |-
-|<font size = "1">US20080317868A1</font>
+|<font color="#0000FF"><u>[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220080317868%22.PGNR.&OS=DN/20080317868&RS=DN/20080317868 US20080317868A1]</u></font>
 |<font size = "1"> </font>
 |<font size = "1"> </font>
@@ Line 358: / Line 404: @@
 |<font size = "1">Nucleotide fraction</font>
 |-
-|<font size = "1">US4497800A</font>
+|<font color="#0000FF"><u>[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4497800.PN.&OS=PN/4497800&RS=PN/4497800 US4497800A]</u></font>
 |<font size = "1"> </font>
 |<font size = "1"> </font>
@@ Line 372: / Line 418: @@
 |align = "center"|<font size = "1"> </font>
 |-
-|<font size = "1">US4499076A</font>
+|<font color="#0000FF"><u>[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4499076.PN.&OS=PN/4499076&RS=PN/4499076 US4499076A]</u></font>
 |<font size = "1">Essential AA<nowiki>’</nowiki>S</font>
 |<font size = "1"> </font>
@@ Line 386: / Line 432: @@
 |align = "center"|<font size = "1">x</font>
 |-
-|<font size = "1">US4837219A</font>
+|<font color="#0000FF"><u>[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4837219.PN.&OS=PN/4837219&RS=PN/4837219 US4837219A]</u></font>
 |<font size = "1">L-Tyrosine, L-Phenylalanime, L-Leucine</font>
 |<font size = "1"> </font>
@@ Line 400: / Line 446: @@
 |align = "center"|<font size = "1">x</font>
 |-
-|<font size = "1">US5437880A</font>
+|<font color="#0000FF"><u>[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5437880.PN.&OS=PN/5437880&RS=PN/5437880 US5437880A]</u></font>
 |<font size = "1"> </font>
 |align = "center"|<font size = "1">x</font>
@@ Line 414: / Line 460: @@
 |<font size = "1">Carotenoids</font>
 |-
-|<font size = "1">WO1994015488A2</font>
+|<font color="#0000FF"><u>[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO9415488&F=0 WO1994015488A2]</u></font>
 |<font size = "1"> </font>
 |align = "center"|<font size = "1">x</font>
@@ Line 430: / Line 476: @@
 |align = "center" bgcolor = "#FFCC99" colspan = "13"|<font size = "1">'''Foodstuff'''</font>
 |-
-|<font size = "1">US20050208191A1</font>
+|<font color="#0000FF"><u>[http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220050208191%22.PGNR.&OS=DN/20050208191&RS=DN/20050208191 US20050208191A1]</u></font>
 |<font size = "1"> </font>
 |<font size = "1"> </font>
-|align = "center"|<font size = "1">x</font>
+|<font size = "1">x</font>
 |<font size = "1"> </font>
 |<font size = "1"> </font>
@@ Line 440: / Line 486: @@
 |<font size = "1"> </font>
 |<font size = "1"> </font>
-|align = "center"|<font size = "1">x</font>
+|<font size = "1">x</font>
 |<font size = "1">Sesame seed paste Sesame seed</font>
 |<font size = "1">Whole wheat, Roasted (defatted) soy Peanut paste, Wheat germ (roasted), Non fat dry milk</font>
 |-
-|<font size = "1">WO2005087018A1</font>
+|<font color="#0000FF"><u>[http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2005087018&F=0 WO2005087018A1]</u></font>
 |<font size = "1"> </font>
 |<font size = "1"> </font>
@@ Line 451: / Line 497: @@
 |<font size = "1"> </font>
 |<font size = "1"> </font>
-|align = "center"|<font size = "1">x</font>
+|<font size = "1">x</font>
 |<font size = "1"> </font>
 |<font size = "1"> </font>
-|align = "center"|<font size = "1">x</font>
+|<font size = "1">x</font>
 |<font size = "1">Wheat flour, roasted peanut paste, sesame seed, soybean flour</font>
-|align = "center"|<font size = "1">x</font>
+|<font size = "1">x</font>
 |-
 |}
-*'''[[Media:cbt containing compositions.xls|Click here]]''' for excel sheet showing Choline Bitartarate containing composition mentioned in Patents.
+*'''[[Media:cbt composition matrix.xls|Click here]]''' for Composition matrix showing all the ingredients used along with Choline Bitartarate.
 ===Patent Analysis Sheets===
-*'''[[Media:cbt Patent Analysis sheet.xls|Click here for the complete Analysis spread sheet-22 ON Targets]]'''
+*'''[[Media:All Patent Analysis sheet.xls|Click here for all Patents spread sheet - Total count: 444]]'''
+*'''[[Media:cbt Patent Analysis sheet.xls|Click here for the complete Analysis spread sheet ON Target count: 22]]'''
 * '''[[Media:Other than cbt ingredients.xls|Click here]]''' for list of ingredients that are in combination with Choline Bitartarate, obtained from Patents.
@@ Line 489: / Line 538: @@
 ==Dashboard==
-* Click at this link for '''[http://client.dolcera.com/dashboard/dashboard.html?workfile_id=554 Dashboard]'''
+* Click at this link for '''[https://www.dolcera.com/auth/dashboard/dashboard.php?workfile_id=554 Dashboard]'''