Latest revision as of 10:20, 5 November 2009

1 Patent FTO Search for the Generic compound
2 Exact match structures
3 Exact match structures but mentioned as optionally substituted at 4th position of pyrazole of generic structure
4 Relevant structures with missing substituents
5 Relevant structures with substituent variation
- 5.1 Structure-1
  - 5.1.1 EP0080051
- 5.2 Structure-2
  - 5.2.1 US2005159470
6 Other structures
- 6.1 WO2007070607

Patent FTO Search for the Generic compound

Exact match structures

Structure-1 (12(doc1))

DE4124942

X₁ = A-B-C- C(sp2 carbon), X₂ = F-C-D-C(sp2 carbon), X₃ = R₁-N<, X₄ = N, X₅ = R₂-C(sp2 carbon)

X₁: A =H , B = bond, C = (b) under B which is halo substituted phenylene which completely matches with 4^th position substituent of the generic compound
X₂: D = (b) under B is a phenylene(implies a substituted aryl) and F-C- is a substituent on D. It is clear that this will match with R²(substituent aryl) at the 5^th position of pyrazole of the generic structure
X₃: R₁ = Q(alkyl) which matches with R¹(alkyl) at the 1^st position of pyrazole of the generic structure
X₄: N which matches with the 2^nd position of pyrazole of the generic compound
X₅: R₂ = Cl, Br which matches with R³(halogen) at the 3^rdposition of pyrazole of the generic structure

Structure-2 (9(doc2))

WO2007081019

In the above phenyl ring Q is pyrazole.

R²= alkyl which matches with R¹(alkyl) at 1^st position of pyrazole of the generic compound.

R⁴ is halogen which matches with R³(halogen) at 3^rd position of pyrazole of the generic compound

4^th position of above pyrazole is trihalo substituted aryl which matches with substituent at 4^th position of pyrazole of generic compound .

5^th position of pyrazole ring is above substituted aryl which matches with R²(substituted aryl) at the 5^th position of pyrazole of generic compound.

Structure-3 (125(doc2))

JP11130754

Consider left side ring the pyrazole ring

R₁ is 1-4C alkyl which is matching with substituent R¹(first position) of the generic structure

X is Cl so it is matching with the substituent R³(second position) of the generic structure

R₂ is phenyl substituted by halo, 1-4C alkyl, cyano which is matching with the fourth position of the generic structure

In the fifth position pyrazole(heteroaryl) is there…which is matching with the substituent R²(fifth position) of the generic structure.

Structure-4 (109(doc2))

WO2006078610

R₂ is 1-6C alkyl which is matching with substituent R¹(first position) of the generic structure

R₄ is halo matching with the substituent R³ (second position) of the generic structure

R₃ is heteroaryl or phenyl substituted by 1-8C alkyl, halo, CN, 1-6C alkoxy which is matching with the fourth position of the generic structure

In fifth position substituted aryl ring there, which is matching with the substituent R²(fifth position) of the generic structure.

Structure-5 (128(doc2))

US5827602

R₁-R₆=H, F, 1-4C alkyl, phenyl

R₂= 1-4C alkyl which matches with R¹(alkyl) at 1^st position of pyrazole of the generic structure

R₅= F which matches with R³(halo)at 1^st position of pyrazole of the generic structure

R₄= phenyl substituted with an electron with drawing group matches with substituent at 4^th position of pyrazole of generic structure

R₃= substituted aryl which matches with R²(substituted aryl) at 5^th position of pyrazole of the generic structure

Structure-6 (19(doc2))

US 2007100181

R₁-R₂= H, -C₂H₅which matches with R¹(alkyl) at 1^st position of pyrazole of generic structure

R₃= halogen which matches with R³(halogen) at 3^rd position of pyrazole of generic structure

R₄= 6-25C heteroaryl having 1-3 heteroatoms(N)(could be pyridine) with substituents as halo, OH and alkyl which completely resembles substituent at 4^th position of pyrazole of the generic structure

R₅= 6-25C heteroaryl having 1-3 heteroatoms(N)(could be pyridine) with substituents which resembles R²(substituted aryl) at 5^th position of pyrazole of generic structure

Structure-7 (88(doc2))

DE19503827

Q-R₄

Q= above structure

R₄= CR5R6R7 where R₅= 1-4C alkyl, R₆= H so no need of R₇

R₄ matches with R¹(alkyl) at 1^st position of pyrazole of generic structure

R₁= halo matches with R³(halogen) at 3^rd position of pyrazole of generic structure

R₂= alkylaryl substituted by halo matches with substituent at 4^th position of pyrazole of generic structures

R₃= substituted aryl which resembles R²(substituted aryl) at 5^th position of pyrazole of generic structure

Structure-8 (86(doc2))

WO9702252

R₁-R₂= 1-4C alkyl, H matches with R¹(alkyl) at 1^st position of pyrazole of generic structure

R₃= halogen matches with R³(halogen) at 3^rd position of pyrazole of generic structure

R₄= phenyl substituted with electron withdrawing group(halogens) matches with substituent at 4^th position of pyrazole of generic structures

R₅= substituted aryl which resembles R²(substituted aryl) at 5^th position of pyrazole of generic structure

Structure-9 (41(doc2))

JP2005216490

R¹= lower alkyl which matches with R1(alkyl) at 1^st position of pyrazole of the generic structure

R²= halogen which matches with R3(halogen) at 3^rdposition of pyrazole of the generic structure

R³= methoxyphenyl which indicates subtituent at 4^th position of generic structure
R⁴= methoxy phenyl which matches with R²(substituted aryl)at 5^th position of pyrazole of generic structure

Structure-10 (61(doc1))

WO2004063166

Z1= C, Z2= N, Z3= N Which indicates pyrazole ring.

R1= Alkyl which matches with R¹(alkyl) at the 1^st position of pyrazole of the generic compound

R32= halo which matches with R³(halogen) at the 3^rd position of pyrazole of the generic compound

R2(0-8Calkyl) so it may be ’0’C alkyl implies it is simply a bond, bonded to a substituted phenyl ring which matches with R²(substituted aryl) at the 5^th position of pyrazole of the generic structure

U is an aliphatic linker(linker means a bond, aliphatic means saturated. So aliphatic linker means saturated bond which implies a single bond) so it is a bond and X is a single bond linked to substituted aryl with halogens and cycloalkyl as substituents which matches with 4^th position of pyrazole of the generic compound.

Exact match structures but mentioned as optionally substituted at 4th position of pyrazole of generic structure

Structure-1 (84(doc2))

WO9711952

R₁-R₄= 1-8C alkyl, haloalkyl, halo, phenyl(optionally substituted by halo, 1-4C alkyl, haloalkyl, alkoxy,)

R₁= 1-8C alkyl which matches with R¹(1-4C alkyl) at 1^st position of pyrazole of generic structure

R₄= halo which matches with R³(halogen) at 3^rd position of pyrazole of generic structure

R₃= phenyl(optionally substituted by halo, alkoxy) which matches with substituent at 4^th position of pyrazole of the generic structure

R₂= phenyl(optionally substituted) which matches with R²(substituted aryl) at 5^th position of pyrazole of the generic structure

Structure-2 (74(doc2))

WO0130154

R¹= (1-6C)alkyl which matches with R¹(1-4C alkyl) at 1^st position of pyrazole of the generic compound

R²= halo which matches with R³(halogen) at 3^rd position of pyrazole of the generic compound

R³= phenyl optionally substituted with halo, 1-6C alkyl, 1-6C alkoxy which matches with substituent at 4^th position of pyrazole of the generic compound

R⁴= heterocyclyl containing 1 or 2N and optionally substituted which matches with R²(optionally substituted heteroaryl) at 5^th position of the generic compound

Structure-3 (39(doc2))

JP2005272306

A= substituted heteroaryl which matches with R²(substituted aryl) at 5^th position of pyrazole of the generic structure

R¹= alkyl which matches with R¹(alkyl) at 1^st position of pyrazole of generic structure

R³= halogen which matches with R³(halogen) at 3^rd position of pyrazole of generic structure

R²= phenyl optionally substituted by Y(1-6C alkyl), 1-6C alkoxy and matches with subtituent at 4^th position of pyrazole of generic structure

Structure-4 (25(doc2))

US2007066822

R¹-R²= H, -CH₃, -C₂H₅ which matches with R¹(alkyl) at 1^st position of pyrazole of generic structure

R³= halogen which matches with R³(halogen) at 3^rd position of pyrazole of generic structure

R⁴= 6-25C optionally substituted heteroaryl which resembles substituent at 4^th position of pyrazole of the generic structure

R⁵= optionally substituted 6-25C heteroaryl which resembles R²(substituted aryl) at 5^th position of pyrazole of generic structure

Structure-5 (23(doc2))

US2007066854

Z⁺= pyrazolium (substituted at 1-5 R1-R5)

R₁= -CH₃, -C₂H₅ which matches with R¹(alkyl) at 1^st position of pyrazole of generic structure

R₃= halogen which matches with R³(halogen) at 3^rd position of pyrazole of generic structure

R₄= 6-25C aryl optionally substituted by C₂H₅, OH which resembles substituent at 4^th position of pyrazole of the generic structure

R₅= optionally substituted 6-25C heteroaryl which resembles R²(substituted aryl) at 5^th position of pyrazole of generic structure

Structure-6 (90(doc2))

R₄-R₇= alkyl matches with R¹(alkyl) at 1^st position of pyrazole of generic structure; halogen matches with R³(halogen) at 3^rd position of pyrazole of generic structure; optionally substituted aryl which resembles R²(substituted aryl) at 5^th position of pyrazole of generic structure and matches with substituent at 4^th position of pyrazole of generic structures

Structure-7 (92(doc2))

WO9600218

Z= a bond,

R₄ is a pyrazole with substituents as 1-4C alkyl matches with R¹(alkyl) at 1^st position of pyrazole of generic structure; halo matches with R³(halogen) at 3^rd position of pyrazole of generic structure; optionally substituted aryl which resembles R²(substituted aryl) at 5^th position of pyrazole of generic structure and matches with substituent at 4^th position of pyrazole of generic structures

Structure-8 (95(doc2))

WO9524403

R₁= alkyl which matches with R¹(alkyl) at 1^stposition of pyrazole of the generic structure

R₃= halo which matches with R³(halogen) at 3^rd position of pyrazole of the generic structure

R₄= heteroaryl optionally substituted indicating substituent at 4^th position of pyrazole of the generic structure

R₅= optionally substituted heteroaryl which matches with R²(optionally substituted heteroaryl) at 5^th position of pyrazole of the generic structure

Structure-9 (98(doc2))

JP6345728

A= N, B= CR⁴

R⁵= 1-6C alkyl which matches withR¹(alkyl) at 1^st position of pyrazole of the generic structure

R³= halogen which matches with R³(halogen) at 3^rd position of pyrazole of the generic structure

R⁴= phenyl(optionally substituted by halo, CN, alkoxy)indicating substituent at 4^th position of pyrazole of the generic structure

R²= optionally substituted phenyl which matches with R²(optionally substituted aryl) at 5^th position of pyrazole of the generic structure

Structure-10 (34(doc2))

WO2006084262

It is pyrazolium with substituents

R₁-R₅= halogen matches with R³(halogen) at 3^rd position of pyrazole of generic structure; -C₂H₅ matches with R¹(alkyl) at 1^st position of pyrazole of generic structure; 6-20C substituted aryl with substituents as halogen, OH which resembles substituent at 4^th position of pyrazole of the generic structure; R⁵= optionally substituted 6-20C heteroaryl which resembles R²(substituted aryl) at 5^th position of pyrazole of generic structure

Relevant structures with missing substituents

Structure-1

JP09204932

R₆ is 1-3C alkyl which is matching with substituent R¹(first position) of the generic structure

R₇ doesn’t exist.. so it is matching with the second position of the generic structure.

R8 is halogen so it is matching with the substituent R³ (second position) of the generic structure

R₁₁ is phenyl’’’(substituents are missing)’’’ which is matching with the fourth position of the generic structure

R₁₀ is phenyl which is matching with the substituent R²(fifth position) of the generic structure.

Structure-2

WO0018741

Q= pyrazolyl

In the above structure the substituted aryl bonded to Q(pyrazolyl) matches with R²(substituted aryl) at 5^th position of pyrazole of the generic structure

R₁= haloalkyl which matches with R¹(alkyl) at 1^st position of the generic structure

R₂= aryl optionally substituted with halo, lower alkoxy, CN which matches with substituent at 4^th position of pyrazole of the generic structure.

But ’’’R³(halogen) of pyrazole of generic structure is missing’’’ in the above structure

Structure-3

EP335381

D= NR12 , E’’= N, E’= CH, E= CH

R₁₂= alkyl matches with R¹(alkyl) at 1^st position of pyrazole of generic structure

R₇= halo matches with R³(halogen) at 3^rd position of pyrazole of generic structure

R₈= substituted benzene ring matches with substituent at 4^th position(but missing substituents) of pyrazole of generic structures

Above pyrazole ring is attached to a substituted aryl matches with R²(substituted aryl) at 5^th position of pyrazole of generic structure

Structure-4

US5296484

G= NR²⁰, M= N

R¹¹= halo, 1-4C alkyl, phenyl

This structure has substituted aryl at 5^th position of pyrazole of the generic structure

At 4^th position of pyrazole i.e.,aryl has no substituents compared to generic structure

One more substituent is missing on the pyrazole ring

Structure-5

US2006122256

AR²= pyrazol-4-yl optionally substituted by Q(halo, lower alkyl, phenyl)

Q substituted on AR²(pyrazole) indicates R³, R¹ and R⁵of pyrazole of the generic structure

At 4^th substituent of pyrazole one substituent is missing and one substituent is varying

Structure-6

JP2004317641

R⁵= alkyl which matches with R¹(alkyl) at 1^st position of pyrazole of the generic structure

R⁶= halogen which matches with R³(halogen)at 3^rd position of pyrazole of the generic structure

R⁷= phenyl with no substituents. It represents substituent at 4^th position of pyrazole of generic structure with substituents missing

R⁸= phenyl which matches with R²(aryl) at 5^th position of pyrazole of generic structure

Structure-7

JP2004317640

R⁵= alkyl which matches with R¹(alkyl) at 1^st position of pyrazole of the generic structure

R⁶= halogen which matches with R³(halogen)at 3^rdposition of pyrazole of the generic structure

R⁷= phenyl with no substituents. It represents substituent at 4^th position of pyrazole of generic structure with substituents missing

R⁸= phenyl which matches with R²(aryl) at 5^th position of pyrazole of generic structure

Structure-8

US2005135045

R= 1-4C alkyl, halogen , phenyl

R= alkyl which matches with R¹(alkyl) at 1^st position of pyrazole of the generic structure

R= halogen which matches with R³(halogen)at 3^rd position of pyrazole of the generic structure

R= phenyl with no substituents. It represents substituent at 4^th position of pyrazole of generic structure with substituents missing

R= phenyl which matches with R²(aryl) at 5^th position of pyrazole of generic structure

Structure-9

WO2006124776

R¹= H, R²= halogen, R³= pyrazole with substituents, R⁵= H, R⁶= H

R³ is a pyrazole ring with substituents as:

-CH₃ matches with R¹(alkyl) of pyrazole of the generic structure

Above ring matches with subtituent at 4^th position of pyrazole of the generic structure

R³ and R² of pyrazole of generic structure are missing

Structure-10

WO2007038363

R¹= H, R²= halogen, R³= pyrazole with substituents, R⁵= H, R⁶= H

R³is defined as 3-25C substituted heteroaryl having 1-3 heteroatoms of N(so can be pyrazole) in which the substituents are -CH₃, halogen:

-CH₃ matches with R¹(alkyl) of pyrazole of the generic structure and halogen matches with R³(halogen) of pyrazole of the generic structure

Above ring matches with subtituent at 4^th position of pyrazole of the generic structure

R²(substituted aryl) of pyrazole of generic structure missing

Structure-11

US2007100184

R₁= H

R₂= -C₂H₅which matches with R¹(alkyl) at 1^st position of pyrazole of generic structure

R₃= halogen which matches with R³(halogen) at 3^rd position of pyrazole of generic structure

R₄= optionally substituted 6-25C heteroaryl with 1-3 of O, N, S or with 1-3 of CH₃, C₂H₅, 3-25, preferably 3-20C straight , branched or cyclic alkane or alkene optionally substituted with halogens which resembles substituent at 4^th position of pyrazole of the generic structure but R⁷ of pyrazole of generic structure is missing

R₅= optionally substituted 6-25C heteroaryl which resembles R²(substituted aryl) at 5^th position of pyrazole of generic structure

Structure-12

US2005020646

R^a= pyrazolyl optionally substituted with 1-3 substituents of R¹¹ or 1-4C alkyl

R¹¹ is defined as halo matches with R³(halogen) at 3^rd position of pyrazole of generic structure; pyridyl which resembles R²(substituted aryl) at 5^th position of pyrazole of generic structure; pyridyl matches with substituent at 4^th position of pyrazole of generic structures but R⁷ of generic structure is missing

Structure-13

EP548680

X¹= het

Het = pyrazolyl with substituents alkyl matches with R¹(alkyl) at 1^st position of pyrazole of generic structure; halo matches with R³(halogen) at 3^rd position of pyrazole of generic structure; phenyl matches with substituent at 4^th position(but missing substituents) of pyrazole of generic structures

Above aryl ring is a substituent on X¹ which resembles R²(substituted aryl) at 5^th position of pyrazole of generic structure

Structure-14

WO2003087062

G= above pyrazole

R₃= alkyl matches with R¹(alkyl) at 1^st position of pyrazole of generic structure

R₄= halo matches with R³(halogen) at 3^rd position of pyrazole of generic structure

R₅= phenyl matches with substituent at 4^th position(but missing substituents) of pyrazole of generic structures

Above given aryl matches with R²(substituted aryl) at 5^th position of pyrazole of generic structure

Structure-15

WO200066562

R₄= alkyl matches with R¹(alkyl) at 1^st position of pyrazole of generic structure

R₅= halo matches with R³(halogen) at 3^rd position of pyrazole of generic structure

R₆= optionally substituted aryl matches with substituent at 4^th position(but missing substituents) of pyrazole of generic structures

Above given aryl matches with R²(substituted aryl) at 5^th position of pyrazole of generic structure

Relevant structures with substituent variation

Structure-1

EP0080051

In the above structure D is N & A,A’,D’ are considered as carbons…so it is forming a pyrazole ring.

In the first position substituent R is 3-iodopropargyl, so it is matching with the substituent R1( first position) of the generic structure.

X is Cl, so it is matching with the substituent R³ (third position) of the generic structure.

Y is 3-chloro-2-nitrophenyl which is matching with the ring of the fourth position of the generic structure but here ’’’substituent variation’’’ is there.

Z is phenyl, so it is matching with the substituent R² (fifth position) of the generic structure.

Structure-2

US2005159470

First position: R₃ is alkyl, so it is matching with the substituent R¹ (first position) of the generic structure.

Second position: X is N, so it is matching with second position of the generic structure.

Third position: X is CR₅ , R₅ is halo so it is matching with the substituent R³ (third position) of the generic structure.

Fourth position: In fourth position substituted aryl ring is present’’’(but it contains five substituents)’’’, is matching with fourth position of the generic structure.

Fifth position: X is CR₅, R₅ is heteroaryl, so it is matching with substituent R²(fifth position) of the generic structure.

Other structures

WO2007070607

R1-H,
R2 is –C2H5 which matches with R1(alkyl) at 1st position of the generic structure
R5 is halo which matches with R3(halogen) at 3rd position of pyrazole of the generic compound
R4 is heteroaryl substituted by C2H5(one substituent is missing) matches with substituent at 4th position of the generic structure.
R3 is substituted heteroaryl which is matching with the substituent R2(fifth position) of the generic structure

@@ Line 1: / Line 1: @@
-==Patent Infringement Search for the Generic compound==
+==Patent FTO Search for the Generic compound==
 [[Image:xxx.jpg|thumb|center|800px]]
 =Exact match structures=
 ==Structure-1 (12(doc1))==
@@ Line 252: / Line 253: @@
 ==Structure-1==
 ===JP09204932===
-[[Image:I.jpg|thumb|center|500px]]
+[[Image:I11.jpg|thumb|center|500px]]
 *<nowiki></nowiki>R<sub>6</sub> is 1-3C alkyl which is matching with substituent R<sup>1</sup>(first position) of the generic structure
@@ Line 265: / Line 266: @@
 ==Structure-2==
 ===[http://v3.espacenet.com/publicationDetails/claims?CC=WO&NR=0018741A2&KC=A2&FT=D&date=20000406&DB=EPODOC&locale=en_EP WO0018741]===
-[[Image:a8.jpg|thumb|center|500px]]
+[[Image:a81.jpg|thumb|center|500px]]
 *<nowiki></nowiki>Q= pyrazolyl
@@ Line 353: / Line 354: @@
 ==Structure-9==
 ===[http://v3.espacenet.com/searchResults?locale=en_EP&NUM=WO2006124776&ST=number&compact=false&DB=EPODOC WO2006124776]===
-[[Image:b1.jpg|thumb|center|500px]]
+[[Image:b11.jpg|thumb|center|500px]]
 R<sup>1</sup>= H, R<sup>2</sup>= halogen, R<sup>3</sup>= pyrazole with substituents, R<sup>5</sup>= H, R<sup>6</sup>= H
@@ Line 367: / Line 368: @@
 ==Structure-10==
 ===[http://v3.espacenet.com/searchResults?locale=en_EP&NUM=WO2007038363&ST=number&compact=false&DB=EPODOC WO2007038363]===
-[[Image:b2.jpg|thumb|center|500px]]
+[[Image:b21.jpg|thumb|center|500px]]
@@ Line 381: / Line 382: @@
 ==Structure-11==
 ===[http://v3.espacenet.com/searchResults?locale=en_EP&NUM=US2007100184&ST=number&compact=false&DB=EPODOC US2007100184]===
-[[Image:b4.jpg|thumb|center|500px]]
+[[Image:b41.jpg|thumb|center|500px]]
@@ Line 399: / Line 400: @@
 ==Structure-12==
 ===[http://v3.espacenet.com/searchResults?locale=en_EP&NUM=US2005020646&ST=number&compact=false&DB=EPODOC US2005020646]===
-[[Image:b6.jpg|thumb|center|500px]]
+[[Image:b61.jpg|thumb|center|500px]]
 R<sup>a</sup>= pyrazolyl optionally substituted with 1-3 substituents of R<sup>11</sup> or 1-4C alkyl
@@ Line 445: / Line 446: @@
 ==Structure-1==
 ===[http://v3.espacenet.com/publicationDetails/claims?CC=EP&NR=0080051A2&KC=A2&FT=D&date=19830601&DB=EPODOC&locale=en_EP EP0080051]===
-[[Image:F.jpg|thumb|center|500px]]
+[[Image:F11.jpg|thumb|center|500px]]
 *<nowiki></nowiki>In the above structure D is N & A,A<nowiki>’</nowiki>,D<nowiki>’</nowiki> are considered as carbons…so it is forming a pyrazole ring.
@@ Line 459: / Line 460: @@
 ==Structure-2==
 ===[http://v3.espacenet.com/publicationDetails/claims?CC=US&NR=2005159470A1&KC=A1&FT=D&date=20050721&DB=EPODOC&locale=en_EP US2005159470]===
-[[Image:D1.jpg|thumb|center|500px]]
+[[Image:D11.jpg|thumb|center|500px]]
 *<nowiki></nowiki>First position: R<sub>3</sub> is alkyl, so it is matching with the substituent R<sup>1</sup> (first position) of the generic structure.
@@ Line 470: / Line 471: @@
 *<nowiki></nowiki>Fifth position: X is CR<sub>5</sub>, R<sub>5</sub> is heteroaryl, so it is matching with substituent R<sup>2 </sup>(fifth position) of the generic structure.
 =Other structures=
 ===[http://v3.espacenet.com/publicationDetails/claims?CC=WO&NR=2007070607A2&KC=A2&FT=D&date=20070621&DB=EPODOC&locale=en_EP  WO2007070607]===
-[[Image:L1.jpg|thumb|center|500px]]
+[[Image:L11.jpg|thumb|center|500px]]
 *R1-H,
 *R2 is –C2H5 which matches with R1(alkyl) at 1st position of the generic structure

Difference between revisions of "Markush Structure Search Sample"

Latest revision as of 10:20, 5 November 2009

Contents

Patent FTO Search for the Generic compound

Exact match structures

Structure-1 (12(doc1))

Structure-2 (9(doc2))

Structure-3 (125(doc2))

Structure-4 (109(doc2))

Structure-5 (128(doc2))

Structure-6 (19(doc2))

Structure-7 (88(doc2))

Structure-8 (86(doc2))

Structure-9 (41(doc2))

Structure-10 (61(doc1))

Exact match structures but mentioned as optionally substituted at 4th position of pyrazole of generic structure

Structure-1 (84(doc2))

Structure-2 (74(doc2))

Structure-3 (39(doc2))

Structure-4 (25(doc2))

Structure-5 (23(doc2))

Structure-6 (90(doc2))

Structure-7 (92(doc2))

Structure-8 (95(doc2))

Structure-9 (98(doc2))

Structure-10 (34(doc2))

Relevant structures with missing substituents

Structure-1

JP09204932

Structure-2

Structure-3

Structure-4

Structure-5

Structure-6

Structure-7

Structure-8

Structure-9

Structure-10

Structure-11

Structure-12

Structure-13

Structure-14

Structure-15

Relevant structures with substituent variation

Structure-1

Structure-2

Other structures

Navigation menu

Search