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<p></p> <p><b>New page</b></p><div>AN <br /> 2006:175 DISSABS Order Number: AAIC821247 (not available for sale by<br /> UMI)<br /> TI <br /> Hormone-sensitive lipase: New roles for an old enzyme<br /> AU <br /> Hansson, Ola Axel [Ph.D.]<br /> CS <br /> Lunds Universitet (Sweden) (0899)<br /> SO <br /> Dissertation Abstracts International, (2005) Vol. 66, No. 4C, p. 766.<br /> Order No.: AAIC821247 (not available for sale by UMI). 147 pages. <br /> ISBN: 91-85439-76-2.<br /> DT <br /> Dissertation<br /> FS <br /> DAI<br /> LA <br /> English<br /> ED <br /> Entered STN: 20060126<br /> Last Updated on STN: 20060126<br /> AB <br /> Hormone-sensitive lipase (HSL) has a unique ability to<br /> hydrolyze a large panel of substrates including acylglycerols, cholesteryl<br /> esters and retinyl esters. HSL is potentially a new drug target for the<br /> treatment of obesity and type II diabetes. However, as HSL is not only<br /> expressed in white adipose tissue (WAT), but also plays significant roles<br /> in other tissues, it is of importance to better understand the different<br /> functions of this enzyme in the body.<br /> In this thesis the aim has been to study the consequences of a<br /> targeted disruption of the HSL gene in the mouse with focus on the<br /> effects in skeletal muscle and WAT.<br /> Expressional and functional analyses of soleus muscle of HSL null<br /> mice suggests an important role of HSL in skeletal muscle metabolism as<br /> the absence of HSL leads to increased glycogen utilization and an<br /> increased amount of lipid droplets, which presumably reflects a metabolic<br /> switch from lipid to carbohydrate metabolism.<br /> A fibre type transformation from slow twitch oxidative fibres to an<br /> enrichment of fast twitch glycolytic fibres in soleus muscle is also<br /> suggested.<br /> Using a proteomic approach a local inflammatory response in WAT is<br /> demonstrated in the non-obese HSL null mouse model. New methodological<br /> aspects of analysing data generated by two-dimensional polyacrylamide gel<br /> electrophoresis are also presented. Increased energy expenditure and<br /> perturbation of adipogenesis are suggested reasons behind the observed<br /> protection against diet-induced obesity in HSL null mice. Results<br /> presented in this thesis suggest an important role of HSL in lipid<br /> signalling and adipogenesis through its action as a retinyl ester<br /> hydrolyze in WAT.<br /> CC <br /> 0379 BIOLOGY, CELL; 0487 CHEMISTRY, BIOCHEMISTRY; 0571 HEALTH SCIENCES,<br /> PATHOLOGY</div>

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