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2003:317841 BIOSIS<br />
DN <br />
PREV200300317841<br />
TI <br />
Downregulation of islet hormone-sensitive lipase during long-term<br />
high-fat feeding. <br />
AU <br />
Winzell, Maria Sorhede [Reprint Author]; Holm, Cecilia; Ahren, Bo<br />
CS <br />
Department of Cell and Molecular Biology, Sec. for Molecular Signalling,<br />
Biomedical Center, Lund University, S-221 84, Lund, Sweden<br />
Maria.Sorhede_Winzell@medkem.lu.se<br />
SO <br />
Biochemical and Biophysical Research Communications, (May 2 2003) Vol.<br />
304, No. 2, pp. 273-278. print. <br />
CODEN: BBRCA9. ISSN: 0006-291X. <br />
DT <br />
Article<br />
LA <br />
English<br />
ED <br />
Entered STN: 9 Jul 2003<br />
Last Updated on STN: 9 Jul 2003<br />
AB <br />
Lipid accumulation in pancreatic beta-cells during high-fat (HF) feeding<br />
may be involved in inducing a defective insulin secretion due to<br />
lipotoxicity. Hormone-sensitive lipase (HSL) is expressed and<br />
active in beta-cells, but its importance for islet dysfunction during the<br />
development of type 2 diabetes is not known. In this study, prolonged<br />
HF feeding of C57BL/6J mice, resulted in decreased HSL expression in<br />
islets, representing only 25 +- 4% of the levels observed in controls.<br />
This was paralleled by triglyceride accumulation and blunted insulin<br />
secretion both in vivo and in vitro. After switching the HF diet to a LF<br />
diet, HSL expression increased 10-fold compared to the HF fed mice.<br />
This was accompanied by reduced triglyceride levels and a restored insulin<br />
secretion. These results support the notion that HSL plays a critical<br />
role in the regulation of intracellular triglyceride levels in beta-cells,<br />
and that down-regulation of the enzyme may serve to protect against fatty<br />
acid-induced islet dysfunction.<br />
CC <br />
Cytology - Animal 02506<br />
Biochemistry studies - Proteins, peptides and amino acids 10064<br />
Biochemistry studies - Lipids 10066<br />
Enzymes - General and comparative studies: coenzymes 10802<br />
Metabolism - Metabolic disorders 13020<br />
Nutrition - General studies, nutritional status and methods 13202<br />
Endocrine - General 17002<br />
Endocrine - Pancreas 17008<br />
Toxicology - General and methods 22501<br />
IT <br />
Major Concepts<br />
Endocrine System (Chemical Coordination and Homeostasis); Enzymology<br />
(Biochemistry and Molecular Biophysics); Nutrition<br />
IT <br />
Parts, Structures, & Systems of Organisms<br />
pancreatic beta-cell: endocrine system<br />
IT <br />
Diseases<br />
type 2 diabetes: endocrine disease/pancreas, metabolic disease<br />
Diabetes Mellitus, Non-Insulin-Dependent (MeSH)<br />
IT <br />
Chemicals & Biochemicals<br />
fat: nutrient; fatty acid; hormone-sensitive lipase:<br />
downregulation; insulin; lipid: toxicity; triglyceride<br />
ORGN <br />
Classifier<br />
Muridae 86375<br />
Super Taxa<br />
Rodentia; Mammalia; Vertebrata; Chordata; Animalia<br />
Organism Name<br />
mouse (common)<br />
Taxa Notes<br />
Animals, Chordates, Mammals, Nonhuman Vertebrates, Nonhuman Mammals,<br />
Rodents, Vertebrates<br />
RN <br />
9001-62-1 (hormone-sensitive lipase)<br />
9004-10-8 (insulin)</div>Admin