View source for Analysis Table

* 17 records/ articles analyzed.
* Below table covers articles (1 to 8), which are talking about inhibition or stimulation of HSL by the chemical compounds.   
{|border="1" cellspacing="0" cellpadding="2" width="100%"
|align = "center" bgcolor = "#FFFF99"|'''S.No.'''
|align = "center" bgcolor = "#FFFF99"|'''Database/ Accession Number'''
|align = "center" bgcolor = "#FFFF99"|'''Focus'''
|align = "center" bgcolor = "#FFFF99"|'''Compounds'''
|align = "center" bgcolor = "#FFFF99"|'''HSL Activity/ Expression'''
|align = "center" bgcolor = "#FFFF99"|'''Function of the compounds'''
|align = "center" bgcolor = "#FFFF99"|'''Disease/Disorder '''(to be treated/ associated with)
|align = "center" bgcolor = "#FFFF99"|'''Dolcera summary'''
|-
|align = "center" bgcolor = "#FFFF99"|'''1'''
|[[BIOSIS / 2006:234207]]
|Expression of the HSL gene by the PPAR gamma and PPAR gamma agonists (rosiglitazone and pioglitazone) in the cultured hepatic cells and differentiating preadipocytes.
|Rosiglitazone
|Up-regulation
|Rosiglitazone up-regulates the HSL gene in liver and skeleton muscle (from an experimental obese rat model).
|Type 2 diabetes
|This study is focused on expression of the HSL gene by PPAR gamma and PPAR gamma agonists (rosiglitazone and pioglitazone) in the cultured hepatic cells and differentiating preadipocytes. Rosiglitazone up-regulates the HSL gene. In conclusion, the study suggests that HSL may be a newly identified PPAR gamma target gene, and up-regulation of HSL may be an important mechanism involved in action of PPAR gamma agonists in type 2 diabetes.
|-
|align = "center" bgcolor = "#FFFF99"|'''2'''
|[[BIOSIS / 2004:316145]]
|Inhibitors of hormone sensitive lipase.
|(5-(2H)-isoxazolonyl) ureas
|Inhibition
|Inhibits HSL
|Diabetes
|(5-(2H)-isoxazolonyl) ureas, inhibitors of hormone-sensitive lipase, an enzyme of potential importance in the treatment of diabetes.
|-
|align = "center" bgcolor = "#FFFF99"|'''3'''
|[[BIOSIS / 2004:256580]]
|Inhibitors of hormone sensitive lipase
|Carbazates
|Inhibition
|Inhibits HSL
|Peripheral insulin resistance (in obese, prediabetic and diabetic individuals)
|Carbazates, inhibitors of the catalytic activity of HSL. HSL is a potential pharmacological target for the prevention of peripheral insulin resistance in obese, prediabetic and diabetic individuals.
|-
|align = "center" bgcolor = "#FFFF99"|'''4'''
|[[BIOSIS / 2004:136651]]
|Inhibitors of hormone sensitive lipase
|Methyl-phenyl- carbamoyl-triazoles
|Inhibition
|Inhibits HSL
|Type 2 diabetes, metabolic syndrome, and impaired glucose tolerance
|Methyl-phenyl-carbamoyl-triazoles are potent HSL inhibitors. HSL regulates fatty acid metabolism makes it an pharmacological target for the treatment of insulin resistant and dyslipidemic disorders where a decrease in delivery of fatty acids to the circulation is desirable in individuals with type 2 diabetes, metabolic syndrome, or impaired glucose tolerance.
|-
|align = "center" bgcolor = "#FFFF99"|'''5'''
|[[BIOSIS / 2002:429399]]
|Inhibitors of hormone sensitive lipase
|Cyclipostins
|Inhibition
|Inhibits HSL
|Type 2 diabetes
|Cyclipostins are inhibitors of hormone-sensitive lipase (HSL). HSL is a key enzyme of lipid metabolism and its control is therefore a target in the treatment of diabetes mellitus.
|-
|align = "center" bgcolor = "#FFFF99"|'''6'''
|[[EMBASE / 1998360072]]
|Moderate dose of fish oil on glycemic control and in vivo insulin action in type 2 diabetic men
|Fish oil
|Up-regulation (increase the amount of mRNA HSL in adipose tissue)
|Up-regulates HSL expression
|Type 2 diabetes
|This study is on effect of a moderate dose of fish oil on glycemic control and ''in vivo'' insulin action in type 2 diabetic men with elevated plasma triacylglycerols. In conclusion, A moderate dose of fish oil did not lead to deleterious effects on glycemic control or whole-body insulin sensitivity in type 2 diabetic men. Fish oil tended to increase the amount of mRNA HSL in adipose tissue.
|-
|align = "center" bgcolor = "#FFFF99"|'''7'''
|[[DISSABS / 2006:21112]]
|Inhibitors of hormonesensitive lipase
|Cyclipostins
|Inhibition
|Inhibits HSL
|Type 2 diabetes
|Article is on synthesis of cyclipostins. Cyclipostins are novel class of natural product possesses strong inhibitory action against hormone-sensitive lipase and has potential in the development of therapeutic agents to regulate lipolysis for the treatment of noninsulin-dependent diabetes mellitus (NIDDM).
|-
|align = "center" bgcolor = "#FFFF99"|'''8'''
|[[DISSABS / 1999:39502]]
|Beta3-adrenergic agonist
|Trecadrine
|Stimulation
|Stimulates HSL activity
|Diabetes, and obesity
|Beta3-adrenergic agonist, trecadrine increases the activity of hormone sensitive lipase and the consumption of oxygen in vitro in white fat.
|-
|}
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