IPMap

Patent/Assignee	Problem	Main Composition	Properties of main ingredient	Nature of composition	Composition action	Composition effect	Mode of administration
US20020052498     Shiseido Co., Ltd.	Male-pattern alopecia and scalp abnormality	(2-substituted oxyphenyl) alkanamide derivative and its salt	Hydrocarbon group of C.sub.3-30 - straight and branched alkyl, alkenyl group and hydrocarbon group having a cycloalkyl ring	Organic compound	Mechanism of action has not been made clear, have an excellent hair growth and regrowth promoting effect	Promotes blood circulation and activates hair follicle	Topical or oral
US20030007941     Pfizer Inc.	Male-pattern alopecia	Thyromimetic compounds (formula 10) with finasteride, minoxidil or cyproterone acetate	Thyromimetic compounds are structurally similar to thyronine or 3,5,3'-triiodo-L-thyronine which is one of the thyroid hormone, produced directly from thyroid gland or, in peripheral tissues	Organic compound	Activates thyroid hormone receptors in hair follicle which in turn promote elasticisation of follicle walls	Increase hair growth, or prevent or delay hair loss	Topical or oral
US20030073616     None	Male-pattern alopecia	Bradykinin antagonist	It's a peptide of plasma origin released from a kininogen precursor by a plasma protease known as kallikrein and is one of the key mediators of inflammation and has mitogenic properties	Peptides/nucleic acid	Inhibit the synthesis of B2 receptors (peptide of kinin group of proteins exist in hair follicle) or compounds involved in modulating the signal transduced by bradykinin by binding to B2 receptor	Regulates growth of epidermal keratinocytes (which produces keratin ie., hair)	Topical
US20030215409     L'OREAL	Male-pattern alopecia	Mixture of an orthodiphenol and a catalytic system comprising a salt and/or an oxide of Mn(II) and/or Zn(II) and a hydrogenocarbonate of an alkaline metal	Hydrogenocarbonates of Na, K, Mg, Ca and mixtures thereof; Precursor of densification from extracts of plants, fruits, vegetables and mixture thereof - Flavonols such as catechin, quercetin, luteolin and epicatechin gallate	Natural extract and organic compound	Oxidizing orthodiphenols with specific pseudo-oxidase in presence of oxygen, thus making possible, through oxidation of the precursor of densification, the coloring of keratinous fibers	Increases hair density and/or promoting regrowth of the keratinous fibers (hair)	Topical or oral
US4874791     Lion Corporation	Male-pattern alopecia	Aliphatic carboxylic acid with vitamin E, estradiol, acetylcholine derivative, serine or methionine, lithospermum root extract, cepharanthine and salicyclic acid	Lower and higher aliphatic carboxylic acid with odd number of carbon atoms and its derivatives from n-hendecanoic acid, n-tridecanoic acid, n-pentadecanoic acid, n-heptadecanoic acid, glyceride acid and metal salt; monoglyceride, diglyceride and triglyceride	Organic compound	N/A	Brings hair follicle from talogen state into a normal anagen state, thus promotes strong hair growth	Topical or injection
US20040071647     L'OREAL	Male-pattern alopecia	Metalloprotease inhibitor (thiol or a hydroxamate) other than chelating calcium ions and growth factors	Metalloproteases (MMPs) are members of a family of proteolitic enzymes (endoproteases) which contain a zinc atom co-ordinated to 3 cysteine residues and one methionine residue in their active site and these MMPs (MMP-9) are present in the internal structures of hair follicles, namely in the inner epithelial sheath (IRS)	Peptides	Reducing the expression of MMPs (Metalloproteases) in the scalp - slow down or inhibit the degradation of the perifollicular matrix (extracellular matrix surround the hair follicle)	Delays migration of follicle to telogenic phase	Topical
US20040157856     WARNER-LAMBERT COMPANY	Male-pattern alopecia	Benzopyran compounds	Act as potassium channel openers	Organic compound	Rapidly metabolized, and cause reduced cardiovascular effects as compared to other known potassium channel openers (i.e. dilates blood vessels)	Prolongs or activates anagen (growth phase) or shortens or delayes catagen (transition phase) and telogen (resting phase) of hair cycle, increases growth rate of hair shafts and hair thickness	Topical
US20050053572     LG HOUSEHOLD & HEALTH CARE LTD	Male-pattern alopecia	Sophora flavescens extract, hinokitiol and nicotinamide	Sophora flavescens contains alkaloids and flavonoids and its leaves contain luteolin-7-glucose and its seeds contains cytosine; Hinokitiol (.beta.-thujaplicin) is a crystalline acid material existing in Taiwan hinoki oil, Aomori, Western Red Cedar oil; Nicotinamide (niacin amide) is a kind of vitamin B complex corresponding to (C6H6N2O), exists as NAD and NADP in living bodies to comprise a co-enzyme	Natural extracts	Sophora flavescens - block DHT; Hinokitiol - promotes function of cell activity; nicotinamide - dilates blood vessels	Inhibiting 5 .alpha.-reductase activity, promoting hair root cell activity functioning by supplying nutrition to hair root and dilates blood vessels	Topical
US20050085467     WARNER-LAMBERT COMPANY	Male-pattern alopecia	New class of 6-sulfonamido-quinolin-2-one and 6-sulfonamido-2-oxo-chromene derivatives	N/A	Organic compound	Inhibit, or decrease, activation of androgen receptor by androgens	Promotes hair growth on scalp by blocking DHT	Topical or oral
US20050118282     Aphios Corporation	Male-pattern alopecia	Saw Palmetto and Sperol originate from Serenoa repens berry	Supercritical fluid isolate of Saw Palmetto, Sperol and their analogs or derivatives	Natural extract	Modulates androgenic activity by inhibiting formation and availability of active androgen in target cells	Inhibits 5.alpha.-reductase activity conversion of testosterone to 5.alpha. DHT	Topical or oral
US20050123577     L'Oreal	Male-pattern alopecia	Prostaglandin EP-3 receptor antagonist, Prostaglandin EP-2 receptor agonist, a prostaglandin EP-4 receptor agonist with Minoxidil, 2,4-diaminopyrimidine 3-oxide, and Aminexil, cyclic AMP	Prostaglandins are biological effectors derived from polyunsaturated fatty acids	Peptides	Minoxidil (designed to mimic nitric oxide's effects) grows hair via prostaglandin-H synthase stimulation. EP-3 and EP-4 are expressed in anagen hair follicles which induce a reduction in the level of cAMP	Increases hair growth and reduces hair loss	Topical
US20050182065     WARNER-LAMBERT COMPANY	Male-pattern alopecia	Benzopyran derivatives	Act as potassium channel openers	Organic compound	Dilates blood vessels	Increases number and period of time of follicles which remain in anagen phase ( i.e. increase the anagen to telogen ratio)	Topical
US2005024436     KPSS-Kao Professional Salon Services GmbH	Scalp related cosmetic problems - greasy hair	Avocado oil	Butyl esters of fatty acids (oleic acid) from avocado oil	Natural extract and organic compound	Reduce sebum of hair and scalp	Anti-fat effect reduces sebum, thus improves hair and scalp feeling	Topical
US20060009427     WARNER-LAMBERT COMPANY LLC	Male-pattern alopecia and excess sebum production	New class of 4-cycloalkoxy benzonitrile derivatives and salts	4-cycloalkoxy benzonitriles contains stereoisomers and geometric isomers and mixtures thereof, phenyl ring, cycloalkyl or cycloalkenyl moiety, bicyclic rings and salts include hydrochloric, hydrobromic, sulphuric, and phosphoric acid and acid metal salts such as sodium monohydrogen orthophosphate, and potassium hydrogen sulfate	Organic compound	Acts as androgen receptor modulators and blocks formation of DHT.	Decrease excess sebum secretion onto the skin and prolongs growth phase of hair cycle (anagen) and increases follicle size.	Topical or oral
US20060009430     BLOTECH INTERNATIONAL CORPORATION	Male-pattern alopecia	Saw Palmetto berry extract, pumpkin seed extract and quercetin, beta-sitosterol	Saw palmetto berry extract are fatty acids and sterols; Pumpkin seeds are a natural source of B-vitamins, zinc, alpha-linolenic acid, amino acids and phytosterols; Quercetin, a phenylbenzopyrone, belongs to a class of water-soluble plant polyphenolic pigments called flavonoids; High levels of beta-sitosterol are found in rice bran, wheat germ, corn oils, and soybeans	Natural extracts	Fatty acids has testosterone-inhibiting effects within prostate. Mechanism of action of the sterols is not well understood. Beta-sitosterol reduce inflammation on scalp and quercetin results in cell growth cycle	Inhibits action of testosterone by inhibiting its conversion to DHT and by blocking DHT binding to androgen recpetor (ARs)	Topical and oral
US20060057093     None	Male-pattern alopecia	Benzyl nicotinate, octyl butyrate, glutamine peptides, monomethylsilanol-hydroxyproline aspartate and pantenol	Silanols are organic derivatives of silicon (protien complex), rich in hydroxyl groups	Organic compound	Acts as a cross-linking agent, integrates tissues with hair bulb. Stimulates activity of transglutaminases (family of enzymes) in scalp cells to increase anchoring of hairs. Divides cells in fibroblasts (cell from which connective tissue (fibrous) develops) and delays hair loss	Enlarges hair follicle and anchor the hair root in the follicle	Topical
EP0279010A2     Kao Corporation	Male-pattern alopecia	Walnut extract (leaves/pericarps) with an organic solvent	5 alpha-reductase inhibiting substance contained in the walnut extract has not been identified yet	Natural extracts	Blocks formation of DHT	Decreasing the rate of telogen and increase the rate of anagen, where the number of anagens is more	Topical or oral
US20060009429     Fundacion Pablo Cassara	Male-pattern alopecia	Pharmacologically active oligonucleotides (INN-18.1, INN-24, INN-71, INN-72, INN-18.2, INN-24.1, INN-73 and INN-76 (ODN))	Oligonucleotides sequences intend to encompass both DNA (deoxiribonucleotide acid, phosphodiester bonds), S-DNA (phosphorothioate, {PTO}, bonds), DNA/S-DNA (PTO) mixed structures or alkylated or methylated chemical structures derived, as substituents on the nitrogene base	Nucleotides	Oligonucleotides inhibit androgen receptor (AR) expression at very low concentrations in skin and hair follicle primary cell cultures, by reaching of, and hibridizing with, specific regions of AR mRNA, triggering the RNAse H digestion of AR mRNA and thus inhibiting AR translation	Anti-androgen - Inhibits androgen receptor expression in skin and dermal papillae cells derived from hair follicles by blocking DHT	Topical
US20060052405     None	Male-pattern alopecia	Testosterone blocker or vascular toner (Flutamide, cyproterone acetate, spironolactone, progesterone, or analogs or derivatives) and minoxidil mixed along with non-retinoid penetration enhancer and sunscreen	Penetration enhancer effectivily delivers testosterone blocker and minoxidil compounds to hair bulb	Peptides	Inhibits 5.alpha.-reductase activity (block DHT) and increase blood flow on the scalp	Stimulate hair growth or inhibit the loss of hair, maintain the health of hair bulbs	Topical
US6447762     Colomer Group Spain, S.L.	Male pattern alopecia	Hop extract, rosemary, extract, swertia extract, silanodiol salicylate	Hops oil contains terpenes and humulene; Rosemary (Rosmarinus officinalis) contains hydroalcohol extract; Swertia japonica is a glycol extract with a swertiamarin; Silanodiol salicylate is a biologically active silicon compound	Natural extract	Inhibit activity of 5-alpha-reductase, protect follicular cell membranes by neutralizing action of oxidation reaction in tissues, stimulates hair follicles and blood circulation to hair root, supply oxygen and nutrients to base of follicle, retain humidity and avoid dehydration of scalp	Prevents hair loss by promoting blood circulation and activates hair follicle	Topical

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